A dual inhibitor of Cdk8 and Cdk19
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AS-2863619

Item No. 30976

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[1-(2-methyl-1H-benzimidazol-6-yl)-1H-imidazo[4,5-c]pyridin-2-yl]-1,2,5-oxadiazol-3-amine, dihydrochloride
CAS Number
2241300-51-4
Molecular Formula
C16H12N8O • 2HCl
Formula Weight
405.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
SMILES
NC1=NON=C1C2=NC(C=NC=C3)=C3N2C4=CC=C(N=C(C)N5)C5=C4.Cl.Cl
InChi Code
InChI=1S/C16H12N8O.2ClH/c1-8-19-10-3-2-9(6-11(10)20-8)24-13-4-5-18-7-12(13)21-16(24)14-15(17)23-25-22-14;;/h2-7H,1H3,(H2,17,23)(H,19,20);2*1H
InChi Key
LHUAALWRORLTCJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $134

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    5 mg

    $479

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    Product Description

    AS-2863619 is a dual inhibitor of cyclin-dependent kinase 8 (Cdk8) and Cdk19 (IC50s = 0.6 and 4.3 nM, respectively).1 It induces Foxp3 expression in isolated mouse naïve T cells when used at a concentration of 1 µM alone or synergistically in combination with TGF-β. AS-2863619 (30 mg/kg) decreases ear edema and induces production of Foxp3+ regulatory T cells (Tregs) in mice. It also reduces disease severity in a mouse model of experimental autoimmune encephalomyelitis (EAE).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sakaguchi, S., Ohkura, N., Mikami, N., et al. Novel compound, and method for producing regulatory T cells. (2019).