A RIPK3 inhibitor
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HS-1371

Item No. 31033

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-quinoline
CAS Number
2158197-70-5
Molecular Formula
C24H24N4O
Formula Weight
384.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 5 mg/mlEthanol: 5 mg/ml
λmax
267 nm
SMILES
CC1=CC=C(C=C1)OC2=CC=NC3=C2C=CC(C4=CN(C5CCNCC5)N=C4)=C3
InChi Code
InChI=1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
InChi Key
VPVLPCIBKVWFDT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $107

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    10 mg

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    50 mg

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    100 mg

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    Product Description

    HS-1371 is a receptor-interacting serine/threonine kinase 3 (RIPK3) inhibitor (IC50 = 20.8 nM).1 It inhibits basal RIPK3 autophosphorylation and TNF-α- or TRAIL-induced necroptosis in HT-29 cells when used at a concentration of 5 µM. It also inhibits necroptosis induced by a TNF-α Smac mimetic and the caspase inhibitor Z-VAD in HeLa cervical and NCI-H2009 lung cancer cells ectopically expressing RIPK3.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, H.-H., Park, S.-Y., Mah, S., et al. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis. Exp. Mol. Med. 50(9), 1-15 (2018).