A mitochondrial uncoupler
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SHS4121705

Item No. 31053

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-[[4-(trifluoromethoxy)phenyl]amino]-[1,2,5]oxadiazolo[3,4-b]pyrazin-5(3H)-one
CAS Number
2379550-82-8
Molecular Formula
C11H6F3N5O3
Formula Weight
313.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/ml
λmax
231, 331 nm
SMILES
FC(F)(F)OC1=CC=C(NC2=NC3=NON=C3N=C2O)C=C1
InChi Code
InChI=1S/C11H6F3N5O3/c12-11(13,14)21-6-3-1-5(2-4-6)15-9-10(20)17-8-7(16-9)18-22-19-8/h1-4H,(H,15,16,18)(H,17,19,20)
InChi Key
PCQQMHFCVPYYAF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $129

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    5 mg

    $203

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    10 mg

    $369

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    Cayman Chemical
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    Product Description

    SHS4121705 is an orally bioavailable mitochondrial uncoupler.1 It increases oxygen consumption rate in L6 rat myoblast cells with an EC50 value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al. 6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitis. J. Med. Chem. 63(11), 6203-6224 (2020).