A non-cysteine reactive derivative of THZ1
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THZ1-R

Item No. 31054

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[[5-chloro-4-(1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-4-[[4-(dimethylamino)-1-oxobutyl]amino]-benzamide
CAS Number
1621523-07-6
Molecular Formula
C31H30ClN7O2
Formula Weight
568.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mM
SMILES
CN(C)CCCC(NC1=CC=C(C(NC2=CC(NC3=NC(C4=CNC5=CC=CC=C54)=C(Cl)C=N3)=CC=C2)=O)C=C1)=O
InChi Code
InChI=1S/C31H30ClN7O2/c1-39(2)16-6-11-28(40)35-21-14-12-20(13-15-21)30(41)36-22-7-5-8-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-10-4-3-9-24(25)27/h3-5,7-10,12-15,17-19,33H,6,11,16H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)
InChi Key
TUERFPPIPKZNKE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $356

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    Product Description

    THZ1-R is a non-cysteine reactive derivative of the cyclin-dependent kinase 7 (Cdk7) inhibitor THZ1 (Item No. 9002215).1 THZ1-R inhibits Cdk7 (IC50s = 142-241 nM) less potently than THZ1 and lacks antiproliferative activity against T cell acute lymphoblastic leukemia (T-ALL) cell lines.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kwiatkowski, N., Zhang, T., Rahl, P.B., et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature 511(7511), 616-620 (2014).