A synthetic estrogen
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Estradiol Cypionate

Item No. 31105

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
estra-1,3,5(10)-triene-3,17β-diol 17-cyclopentanepropanoate
CAS Number
313-06-4
Synonyms
  • Estradiol 17β-Cyclopentanepropionate
  • Estradiol 17-Cypionate
  • NSC 3354
Molecular Formula
C26H36O3
Formula Weight
396.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 15 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/mlEthanol: 20 mg/ml
SMILES
OC1=CC=C2C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@@H]4OC(CCC5CCCC5)=O)=C1
InChi Code
InChI=1S/C26H36O3/c1-26-15-14-21-20-10-8-19(27)16-18(20)7-9-22(21)23(26)11-12-24(26)29-25(28)13-6-17-4-2-3-5-17/h8,10,16-17,21-24,27H,2-7,9,11-15H2,1H3/t21-,22-,23+,24+,26+/m1/s1
InChi Key
UOACKFBJUYNSLK-XRKIENNPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 mg

    $81

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    1 g

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    5 g

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    Product Description

    Estradiol cypionate is a synthetic estrogen and an ester derivative of 17β-estradiol (Item No. 10006315).1,2,3 In vivo, estradiol cypionate (0.1 mg/kg per day) reduces estrogen depletion-induced spikes in basal tail temperature in ovariectomized wild-type, estrogen receptor α knockout (ERα-/-), and ERβ-/- mice.1 It increases the rate of pregnancy in cows induced to ovulate small dominant follicles with gonadotropin-releasing hormone (GnRH).2 Estradiol cypionate also reduces edema and articular joint neutrophil infiltration in an ovariectomized mouse model of zymosan-induced arthritis.3 Formulations containing estradiol cypionate have been used in the treatment of menopausal symptoms and low estrogen levels.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Opas, E.E., Gentile, M.A., Kimmel, D.B., et al. Estrogenic control of thermoregulation in ERαKO and ERβKO mice. Maturitas 53(2), 210-216 (2006).

    2. Jinks, E.M., Smith, M.F., Atkins, J.A., et al. Preovulatory estradiol and the establishment and maintenance of pregnancy in suckled beef cows. J. Anim. Sci. 91(3), 1176-1185 (2013).

    3. Schneider, A.H., Kanashiro, A., Dutra, S.G.V., et al. Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice. Int. Immunopharmacol. 72, 504-510 (2019).