A hypolipidemic agent
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Clinofibrate

Item No. 31109

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2′-[cyclohexylidenebis(4,1-phenyleneoxy)]bis[2-methyl-butanoic acid
CAS Number
30299-08-2
Synonyms
  • S-8527
Molecular Formula
C28H36O6
Formula Weight
468.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30mg/mLDMSO: 15mg/mLEthanol: 30mg/mLEthanol:PBS (pH 7.2) (1:5): 0.16mg/mL
λmax
232 nm
SMILES
OC(C(CC)(C)OC1=CC=C(C2(C3=CC=C(OC(CC)(C)C(O)=O)C=C3)CCCCC2)C=C1)=O
InChi Code
InChI=1S/C28H36O6/c1-5-26(3,24(29)30)33-22-14-10-20(11-15-22)28(18-8-7-9-19-28)21-12-16-23(17-13-21)34-27(4,6-2)25(31)32/h10-17H,5-9,18-19H2,1-4H3,(H,29,30)(H,31,32)
InChi Key
BMOVQUBVGICXQN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Clinofibrate is a hypolipidemic agent.1 It inhibits HMG-CoA reductase (IC50 = 0.47 mM) and stimulates the S-indan-1-ol dehydrogenase activity of the human liver 3α-hydroxysteroid dehydrogenase isoform AKR 1C4 in a concentration-dependent manner.2 Clinofibrate (10 and 30 mg/kg) reduces serum cholesterol and triglyceride levels in rats fed a normal chow pellet diet or a semisynthetic diet containing sucrose as the only carbohydrate source.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Toki, K., Nakamura, Y., Agatsuma, K., et al. Hypolipidemic action of a new aryloxy compound (S-8527) in rats. Atherosclerosis 18(1), 101-108 (1973).

    2. Matsuura, K., Hara, A., Kato, M., et al. Activation of human liver 3α-hydroxysteroid dehydrogenase by clofibrate derivatives. J. Pharmacol. Exp. Ther. 285(3), 1096-1103 (1998).