A ginsenoside with diverse biological activities
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Ginsenoside F1

Item No. 31137

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,6α,12β)-3,6,12-trihydroxydammar-24-en-20-yl β-D-glucopyranoside
CAS Number
53963-43-2
Synonyms
  • GF1
  • Panaxoside A Progenin
Molecular Formula
C36H62O9
Formula Weight
638.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.12 mg/mlEthanol: 10 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]4(C)C[C@H](O)[C@]5([H])[C@@](CC[C@H](O)C5(C)C)(C)[C@@]4([H])C1
InChi Code
InChI=1S/C36H62O9/c1-19(2)10-9-13-36(8,45-31-29(43)28(42)27(41)23(18-37)44-31)20-11-15-34(6)26(20)21(38)16-24-33(5)14-12-25(40)32(3,4)30(33)22(39)17-35(24,34)7/h10,20-31,37-43H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24+,25-,26-,27+,28-,29+,30-,31-,33+,34+,35+,36-/m0/s1
InChi Key
XNGXWSFSJIQMNC-FIYORUNESA-N
Origin
Plant/Panax ginseng
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Ginsenoside F1 (GF1) is a ginsenoside that has been found in P. ginseng and has diverse biological activities.1,2,3,4 It increases cytotoxic degranulation of natural killer (NK) cells against K562 leukemia cells in vitro when used at a concentration of 10 µM and enhances NK cell-mediated lymphoma clearance in vivo.1 GF1 (50 mg/kg) reduces atherosclerotic lesion area, whole body myeloperoxidase (MPO) levels, and aortic root NF-kB, TLR4, and LOX-1 levels in ApoE-/- mice.2 It increases microvessel density and improves focal cerebral blood perfusion in a rat model of ischemic stroke induced by middle cerebral artery occlusion (MCAO).3 GF1 also restores spatial working memory, but not context-dependent fear memory, in the APP/PS1 transgenic mouse model of Alzheimer's disease.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kwon, H.-J., Lee, H., Choi, G.-E., et al. Ginsenoside F1 promotes cytotoxic activity of NK cells via insulin-like growth factor-1-dependent mechanism. Front. Immunol. 9, 2785 (2018).

    2. Qin, M., Luo, Y., Lu, S., et al. Ginsenoside F1 ameliorates endothelial cell inflammatory injury and prevents atherosclerosis in mice through A20-mediated suppression of NF-κB signaling. Front. Pharmacol. 8, 953 (2017).

    3. Zhang, J., Liu, M., Huang, M., et al. Ginsenoside F1 promotes angiogenesis by activating the IGF-1/IGF1R pathway. Pharmacol. Res. 144, 292-305 (2019).

    4. Han, J., Oh, J.-P., Yoo, M., et al. Minor ginsenoside F1 improves memory in APP/PS1 mice. Mol. Brain 12(1), 77 (2019).