A steroid glycoside with diverse biological activities
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Ginsenoside Rh1

Item No. 27318

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,6α,12β)-3,12,20-trihydroxydammar-24-en-6-yl, β-D-glucopyranoside
CAS Number
63223-86-9
Synonyms
  • 20(S)-Ginsenoside Rh1
  • Prosapogenin A2
  • Sanchinoside Rh1
Molecular Formula
C36H62O9
Formula Weight
638.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@](O)(C)CC/C=C(C)/C)(C)[C@]3(C)C[C@H](O[C@@]4([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O4)[C@]5([H])[C@@](CC[C@H](O)C5(C)C)(C)[C@@]3([H])C1
InChi Code
InChI=1S/C36H62O9/c1-19(2)10-9-13-36(8,43)20-11-15-34(6)26(20)21(38)16-24-33(5)14-12-25(39)32(3,4)30(33)22(17-35(24,34)7)44-31-29(42)28(41)27(40)23(18-37)45-31/h10,20-31,37-43H,9,11-18H2,1-8H3/t20-,21+,22-,23+,24+,25-,26-,27+,28-,29+,30-,31+,33+,34+,35+,36-/m0/s1
InChi Key
RAQNTCRNSXYLAH-RFCGZQMISA-N
Origin
Plant/Panax ginseng
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    50 mg

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    Product Description

    Ginsenoside Rh1 is a steroid glycoside and saponin that has been found in red ginseng and has diverse biological activities.1,2 It inhibits expression of matrix metalloproteinase-1 (MMP-1), MMP-3, and MMP-9 induced by phorbol 12-myristate 13-acetate (PMA; Item No. 10008014) in U87MG and U373MG human astroglioma cells in a concentration-dependent manner.2 Ginsenoside Rh1 (300 μM) also inhibits PMA-induced invasion and migration of these cell lines in Matrigel™ invasion and wound healing assays, respectively. It inhibits LPS-induced increases in nitrite accumulation, prostaglandin E2 (PGE2; Item No. 14010) synthesis, and inducible nitric oxide synthase (iNOS) protein levels in RAW 264.7 cells and inhibits histamine release induced by compound 48/80 (Item No. 22173) in rat peritoneal mast cells (IC50 = 37 μM).3 Ginsenoside Rh1 (25 mg/kg, i.p.) inhibits IgE-induced passive cutaneous anaphylaxis reactions in mice by 87%. Ginsenoside Rh1 is also a metabolite of ginsenoside Re (Item No. 15330) and ginsenoside Rg1 (Item No. 15315) formed by intestinal microflora.2,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tam, D.N.H., Truong, D.H., Nguyen, T.T.H., et al. Ginsenoside Rh1: A systematic review of its pharmacological properties. Planta Med. 84(3), 139-152 (2018).

    2. Jung, J.S., Ahn, J.H., Le, T.K., et al. Protopanaxatriol ginsenoside Rh1 inhibits the expression of matrix metalloproteinases and the in vitro invasion/migration of human astroglioma cells. Neurochem. Int. 63(2), 80-86 (2013).

    3. Park, E.K., Choo, M.K., Han, M.J., et al. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int. Arch. Allergy. Immunol. 133(2), 113-120 (2004).

    4. Peng, D., Wang, H., Qu, C., et al. Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics. Chin. Med. 7, 2 (2012).