The end product of the creatine-creatine phosphate energy shuttle
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Labeled Version(s)
16763Creatinine-d3
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Product Categories

Product Type

Biochemicals

Research Area

Creatinine

Item No. 31164

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one
CAS Number
60-27-5
Synonyms
  • NSC 13123
Molecular Formula
C4H7N3O
Formula Weight
113.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
λmax
236 nm
SMILES
O=C1CN(C)C(N)=N1
InChi Code
InChI=1S/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)
InChi Key
DDRJAANPRJIHGJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 g

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    Product Description

    Creatinine is the end product of the creatine-creatine phosphate energy shuttle.1 It is formed by the spontaneous and non-enzymatic cyclization of creatine, as well as from creatine phosphate via a phosphorylcreatinine intermediate, in skeletal muscle and brain. Creatinine levels are increased in the urine after exercise in mice and in the plasma of rats fed a high-protein diet for 20 months.2,3 Serum creatinine levels have been used to estimate the glomerular filtration rate (GFR) and as a marker of renal dysfunction.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wyss, R.H., Karsznia, R., Heinrichs, W.L., et al. Inhibition of uterine receptor binding of estradiol by anti-estrogens (clomiphene and CL-868). J. Clin. Endocrinol. Metab. 28(12), 1824-1828 (1968).

    2. Maxwell, A.J., Schauble, E., Bernstein, D., et al. Limb blood flow during exercise is dependent on nitric oxide. Circulation 98(4), 369-374 (1998).

    3. Bertani, T., Zoja, C., Abbate, M., et al. Age-related nephropathy and proteinuria in rats with intact kidneys exposed to diets with different protein content. Lab. Invest. 60(2), 196-204 (1989).

    4. Delanaye, P., Cavalier, E., and Pottel, H. Serum creatinine: Not so simple!. Nephron 136(4), 302-308 (2017).