A 5-HT1D receptor antagonist
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BRL 15572

Item No. 31191

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(3-chlorophenyl)-α-(diphenymethyl)-1-piperazineethanol, dihydrochloride
CAS Number
193611-72-2
Molecular Formula
C25H27ClN2O • 2HCl
Formula Weight
479.9
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 1 mg/ml
λmax
250, 291 nm
SMILES
OC(C(C1=CC=CC=C1)C2=CC=CC=C2)CN3CCN(C4=CC(Cl)=CC=C4)CC3.Cl.Cl
InChi Code
InChI=1S/C25H27ClN2O.2ClH/c26-22-12-7-13-23(18-22)28-16-14-27(15-17-28)19-24(29)25(20-8-3-1-4-9-20)21-10-5-2-6-11-21;;/h1-13,18,24-25,29H,14-17,19H2;2*1H
InChi Key
WPEXRXMQMPOHIO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

    $68

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    50 mg

    $219

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    100 mg

    $268

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    Product Description

    BRL 15572 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1D (Ki = 0.013 µM in CHO cell membranes expressing the human receptor).1 It is selective for 5-HT1D over several other G protein-coupled 5-HT receptor subtypes with Ki values ranging from 0.25 to 6.3 µM but does bind 5-HT1A and 5-HT2B receptors (Kis = 0.02 and 0.04 µM, respectively). BRL 15572 also acts as a partial agonist at 5-HT1D receptors (EC50 = 0.008 µM in a [35S]GTPγS binding assay).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Price, G.W., Burton, M.J., Collin, L.J., et al. SB-216641 and BRL-15572 – compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 356(3), 312-320 (1997).