A CYP450 substrate
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7-Ethoxycoumarin

Item No. 31215

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-ethoxy-2H-1-benzopyran-2-one
CAS Number
31005-02-4
Molecular Formula
C11H10O3
Formula Weight
190.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.50 mg/mlDMSO: 15 mg/ml
λmax
218, 322 nm
SMILES
O=C1C=CC2=CC=C(OCC)C=C2O1
InChi Code
InChI=1S/C11H10O3/c1-2-13-9-5-3-8-4-6-11(12)14-10(8)7-9/h3-7H,2H2,1H3
InChi Key
LIFAQMGORKPVDH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    100 mg

    $36

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    250 mg

    $73

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    500 mg

    $128

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    1 g

    $186

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    Product Description

    7-Ethoxycoumarin is a substrate for cytochrome P450 (CYP).1 It undergoes O-deethylation by various CYP isoforms, including CYP1A1, -1A2, and -2B in mice and CYP2E1 in humans. 7-Ethoxycoumarin has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Okamatsu, G., Komatsu, T., Kubota, A., et al. Identification and functional characterization of novel feline cytochrome P450 2A. Xenobiotica 45(6), 503-510 (2015).

    2. Kajbaf, M., Ricci, R., Zambon, S., et al. Contribution of rat intestinal metabolism to the xenobiotics clearance. Eur. J. Drug Metab. Pharmacokinet. 38(1), 33-41 (2013).

    3. Kölln, C., and Reichl, S. Cytochrome P450 activity in ex vivo cornea models and a human cornea construct. J. Pharm. Sci. 105(7), 2204-2212 (2016).