A sulfonamide antibiotic with antiprotozoal activity
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Sulfaclozine (sodium salt)

Item No. 31223

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-amino-N-(6-chloro-2-pyrazinyl)-benzenesulfonamide, monosodium salt
CAS Number
23307-72-4
Synonyms
  • Sulfachloropyrazine
  • Sulphachloropyrazine
Molecular Formula
C10H8ClN4O2S • Na
Formula Weight
306.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
261, 323 nm
SMILES
ClC1=CN=CC([N-]S(C2=CC=C(N)C=C2)(=O)=O)=N1.[Na+]
InChi Code
InChI=1S/C10H8ClN4O2S.Na/c11-9-5-13-6-10(14-9)15-18(16,17)8-3-1-7(12)2-4-8;/h1-6H,12H2;/q-1;+1
InChi Key
NIUFFODHMKLSCH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Sulfaclozine is a sulfonamide antibiotic with antiprotozoal activity.1,2 Dietary administration of sulfaclozine reduces cecal lesion score and oocyst production in a chick model of E. tenella infection in a dose-dependent manner.1 It increases average survival time in a mouse model of T. gondii infection when administered at a dose of 250 mg/kg per day.2 Sulfaclozine has been found in chicken muscle samples from domestic markets and as an environmental contaminant in fish pond water, biogas digester water, and lagoon wastewater from pig farms.3,4 Formulations containing sulfaclozine have been used in the treatment of coccidiosis in poultry.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Matsuzawa, T., and Kitano, N. Studies on the mode of action of sulfachloropyrazine against coccidia in chickens. Japan Poultry Sci. 11(3), 75-85 (1974).

    2. Zeng, Y.-B., Zhu, S.-H., Dong, H., et al. Great efficacy of sulfachloropyrazine-sodium against acute murine toxoplasmosis. Asian Pac. J. Trop. Biomed. 2(1), 70-75 (2012).

    3. Cao, G., Zhan, J., Shi, X., et al. Analysis of 140 veterinary drugs and other contaminants in poultry muscle by ultrahigh-performance liquid chromatography–tandem mass spectrometry. Chromatographia 81, 707-718 (2018).

    4. Hu, F.-Y., He, L.-M., Yang, J.-W., et al. Determination of 26 veterinary antibiotics residues in water matrices by lyophilization in combination with LC-MS/MS. J. Chromatogr. B 949-950, 79-86 (2014).