An internal standard for the quantification of 4-deoxy nivalenol
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Unlabeled Version(s)
114284-deoxy Nivalenol
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4-deoxy Nivalenol-13C15

Item No. 31249

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,7α)-12,13-epoxy-3,7,15-trihydroxy-trichothec-9-en-8-one-13C15
CAS Number
911392-36-4
Synonyms
  • Vomitoxin-13C15
  • Deoxynivalenol-13C15
  • DON-13C15
Molecular Formula
[13C]15H20O6
Formula Weight
311.2
Purity
≥98%
Formulation
A 25 µg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
Acetonitrile: soluble
SMILES
[13CH3][13C]1=[13CH][13C@]2([H])[13C@]([13C@]([13CH2][13C@H]3O)([13CH3])[13C@]4([13CH2]O4)[13C@]3([H])O2)([13CH2]O)[13C@H](O)[13C]1=O
InChi Code
InChI=1S/C15H20O6/c1-7-3-9-14(5-16,11(19)10(7)18)13(2)4-8(17)12(21-9)15(13)6-20-15/h3,8-9,11-12,16-17,19H,4-6H2,1-2H3/t8-,9-,11-,12-,13-,14-,15+/m1/s1/i1+1,2+1,3+1,4+1,5+1,6+1,7+1,8+1,9+1,10+1,11+1,12+1,13+1,14+1,15+1
InChi Key
LINOMUASTDIRTM-YGEUXOLBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1.2 ml

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    Product Description

    4-deoxy Nivalenol-13C15 is intended for use as an internal standard for the quantification of 4-deoxy nivalenol (Item No. 11428) by GC- or LC-MS. 4-deoxy Nivalenol is a trichothecene mycotoxin that has been found in Fusarium.1 It binds to eukaryotic ribosomes and inhibits protein synthesis in mice when administered at doses ranging from 5 to 25 mg/kg. 4-deoxy Nivalenol (0.1 and 0.2 mg/kg) induces emesis in pigs and decreases feed consumption in pigs when administered at a dose of 40 ppb in the diet.2 It induces lethality in mice (LD50 = 46-78 mg/kg).3 4-deoxy Nivalenol has been found in F. graminearum-infected cereal grains such as wheat, barley, and corn.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pestka, J.J., and Smolinski, A.T. Deoxynivalenol: Toxicology and potential effects on humans. J. Toxicol. Environ. Health B Crit. Rev. 8(1), 39-69 (2005).

    2. Forsyth, D.M., Yoshizawa, T., Morooka, N., et al. Emetic and refusal activity of deoxynivalenol to swine. Appl. Environ. Microbiol. 34(5), 547-552 (1977).

    3. Pestka, J.J. Deoxynivalenol: Mechanisms of action, human exposure, and toxicological relevance. Arch. Toxicol. 84(9), 663-679 (2010).