Zearalenone-¹³C₁₈

Zearalenone-¹³C₁₈ is intended for use as an internal standard for the quantification of zearalenone (Item No. 11353) by GC- or LC-MS. Zearalenone is a mycotoxin that has been found in Fusarium and has estrogenic activities.¹ It binds to human estrogen receptor α (ERα) and ERβ (IC₅₀s = 9 and 5.8 nM, respectively).² Zearalenone induces precocious development of mammary tissues in young female pigs and prepucial enlargement in young male pigs.³ Zearalenone (1.5-5 mg/kg of diet) induces hyperestrogenism in pigs. It also induces degeneration of meiotic chromatin in oocytes and reduces fertility in pigs when administered at a dose of 200 µg/kg.⁴ Zearalenone has been found as a contaminant in wheat, maize, and barley and livestock feeds.^3,4

WARNING This product is not for human or veterinary use.

1. Zinedine, A., Soriano, J.M., Moltó, J.C., et al. Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: An oestrogenic mycotoxin. Food Chem. Toxicol. 45(1), 1-18 (2007).

2. Kuiper, G.G.J.M., Lemmen, J.G., Carlsson, B., et al. Interaction of estrogenic chemicals and phytoestrogens with estrogen receptor β. Endocrinology 139(10), 4252-4263 (1998).

3. Richard, J.L. Some major mycotoxins and their mycotoxicoses—an overview. Int. J. Food Microbiol. 119(1-2), 3-10 (2007).

4. Tiemann, U., and Dänicke, S. In vivo and in vitro effects of the mycotoxins zearalenone and deoxynivalenol on different non-reproductive and reproductive organs in female pigs: A review. Food Addit. Contam. 24(3), 306-314 (2007).