An internal standard for the quantification of mozavaptan
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Unlabeled Version(s)
16664Mozavaptan (hydrochloride)
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Mozavaptan-d6

Item No. 31321

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[[5-(dimethyl-d6-amino)-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]carbonyl]phenyl]-2-methyl-benzamide
CAS Number
2750534-83-7
Molecular Formula
C27H23D6N3O2
Formula Weight
433.6
Purity
≥99% deuterated forms (d1-d6)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Methanol (1:1): SolubleDMF: SolubleDMSO: Soluble
SMILES
CC1=CC=CC=C1C(NC2=CC=C(C(N3C(C=CC=C4)=C4C(N(C([2H])([2H])[2H])C([2H])([2H])[2H])CCC3)=O)C=C2)=O
InChi Code
InChI=1S/C27H29N3O2/c1-19-9-4-5-10-22(19)26(31)28-21-16-14-20(15-17-21)27(32)30-18-8-13-24(29(2)3)23-11-6-7-12-25(23)30/h4-7,9-12,14-17,24H,8,13,18H2,1-3H3,(H,28,31)/i2D3,3D3
InChi Key
WRNXUQJJCIZICJ-XERRXZQWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $169

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    1 mg

    $303

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    Product Description

    Mozavaptan-d6 is intended for use as an internal standard for the quantification of mozavaptan (Item No. 16664) by GC- or LC-MS. Mozavaptan is an orally bioavailable antagonist of vasopressin V2 receptors (Ki = 9.42 nM in HeLa cells expressing the human receptor).1,2 It is selective for vasopressin V2 over V1 receptors (IC50s = 14 and 1,200 nM, respectively) in radioligand binding assays using rat kidney and rat liver membranes that endogenously express high levels of vasopressin V2 and V1 receptors, respectively.1 Mozavaptan (10-30 mg/kg, p.o.) increases urine volume and decreases urine osmolality, indicating aquaresis, in conscious rats. It reduces decreases in urine flow and increases in urine osmolality induced by arginine vasopressin (AVP; Item No. 24154) in anesthetized rats when administered intravenously at doses ranging from 10 to 100 µg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yamamura, Y., Ogawa, H., Yamashita, H., et al. Characterization of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist. Br. J. Pharmacol. 105(4), 787-791 (1992).

    2. Nakamura, S., Itoh, S., Fujiki, H., et al. Binding affinities of mozavaptan hydrochloride (OPC-31260) for vasopressin receptors. Jap. Pharmacol. Ther. 34(7), 827-834 (2006).