A CaMKK inhibitor
Related Products
Alternative(s)
15325STO-609 (acetate)
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

STO-609

Item No. 31358

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid
CAS Number
52029-86-4
Molecular Formula
C19H10N2O3
Formula Weight
314.3
Purity
≥95% (mixture of isomers)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
100 mM NaOH: 10 mg/mlDMSO: 1 mg/ml
λmax
221, 287, 297, 390 nm
SMILES
O=C(C(C=CC(C1=NC2=C(N13)C=CC=C2)=C45)=C4C=CC=C5C3=O)O.O=C(C6=CC=C7)N8C9=C(C=CC=C9)N=C8C%10=C6C7=CC(C(O)=O)=C%10
InChi Code
InChI=1S/2C19H10N2O3/c22-18-12-5-3-4-10-8-11(19(23)24)9-13(16(10)12)17-20-14-6-1-2-7-15(14)21(17)18;22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h2*1-9H,(H,23,24)
InChi Key
RNMGNCQBZCDYFU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $41

    Add

    5 mg

    $119

    Add

    10 mg

    $215

    Add

    25 mg

    $389

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    STO-609 is a calcium/calmodulin-dependent protein kinase kinase (CaMKK) inhibitor (IC50s = 120 and 40 ng/ml for CaMKKα and CaMKKβ, respectively).1 It is selective for CaMKKs over CaMKI, CaMKII, CaMKIV, MLCK, PKC, PKA, and p42 MAPK (IC50s = ≥10,000 ng/ml for all). STO-609 inhibits phosphorylation of CaMKI and AMP-activated protein kinase (AMPK) in chicken sperm in the presence of extracellular calcium, as well as reduces chicken sperm motility, in a concentration-dependent manner.2 It decreases hypothalamic neuropeptide Y (Npy) and agouti-related protein (Agrp) expression and cumulative food intake in mice when administered intracerebroventricularly as a 20 μM solution at a continuous rate of 0.5 μL/hour .3 STO-609 (3 μg/animal, i.c.v.) increases cortical, striatal, and total infarct volume in a mouse model of focal transient cerebral ischemia induced by middle cerebral artery occlusion (MCAO).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tokumitsu, H., Inuzuka, H., Ishikawa, Y., et al. STO-609, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase kinase. The Journal of Biological Chemisty 278(13), 10908-10913 (2013).

    2. Nguyen, T.M.D., Combarnous, Y., Praud, C., et al. Ca2+/calmodulin-dependent protein kinase kinases (CaMKKs) effects on AMP-activated protein kinase (AMPK) regulation of chicken sperm functions. PLoS One 11(1), e0147559 (2016).

    3. Anderson, K.A., Ribar, T.J., Lin, F., et al. Hypothalamic CaMKK2 contributes to the regulation of energy balance. Cell Metab. 7(5), 377-388 (2008).

    4. McCullough, L.D., Tarabishy, S., Liu, L., et al. Inhibition of calcium/calmodulin-dependent protein kinase kinase β and calcium/calmodulin-dependent protein kinase IV is detrimental in cerebral ischemia. Stroke 44(9), 2559-2566 (2013).