An inhibitor of ferroptosis
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RC574

Item No. 31408

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,6-bis(1,1-dimethylethyl)-4-(2-thienylseleno)-phenol
CAS Number
2584411-87-8
Molecular Formula
C18H24OSSe
Formula Weight
367.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
239 nm
SMILES
OC1=C(C(C)(C)C)C=C([Se]C2=CC=CS2)C=C1C(C)(C)C
InChi Code
InChI=1S/C18H24OSSe/c1-17(2,3)13-10-12(21-15-8-7-9-20-15)11-14(16(13)19)18(4,5)6/h7-11,19H,1-6H3
InChi Key
CUSKUKDTRDQWBN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $63

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    5 mg

    $229

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    10 mg

    $392

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    Product Description

    RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol (Item No. 15043).1 It inhibits glutamate-induced cell death in HT22 cells (IC50 = 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor RSL3 in HT22 cells when used at concentrations ranging from 62.5 to 1,000 nM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bueno, D.C., Canto, R.F.S., de Souza, V., et al. New probucol analogues inhibit ferroptosis, improve mitochondrial parameters, and induce glutathione peroxidase in HT22 cells. Mol. Neurobiol. 57(8), 3273-3290 (2020).