A non-steroidal androgen receptor antagonist
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PF-998425

Item No. 31442

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(1R,2R)-2-hydroxycyclohexyl]-2-(trifluoromethyl)-benzonitrile
CAS Number
1076225-27-8
Molecular Formula
C14H14F3NO
Formula Weight
269.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
SMILES
O[C@H]1[C@@H](C2=CC(C(F)(F)F)=C(C#N)C=C2)CCCC1
InChi Code
InChI=1S/C14H14F3NO/c15-14(16,17)12-7-9(5-6-10(12)8-18)11-3-1-2-4-13(11)19/h5-7,11,13,19H,1-4H2/t11-,13-/m1/s1
InChi Key
MENRRRXHFQYXDW-DGCLKSJQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $41

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    5 mg

    $108

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    10 mg

    $196

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    Product Description

    PF-998425 is a non-steroidal androgen receptor antagonist (IC50 = 43 nM in a cell-based assay).1 It binds to the androgen receptor (IC50 = 37 nM in a radioligand binding assay) and is selective for the androgen receptor over the progesterone receptor (IC50 = >10,000 nM). Topical administration of PF-998425 (3% twice per day) increases hair growth in a mouse model of hair growth, as well as reduces ear sebum in male Syrian golden hamsters (ED50 = 0.4% twice per day).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, J.J., Iula, D.M., Nguyen, M.N., et al. Rational design and synthesis of 4-((1R,2R)-2-hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a novel, nonsteroidal androgen receptor antagonist devoid of phototoxicity for dermatological indications. J. Med. Chem. 51(21), 7010-7014 (2008).