An adenosine A2A and A2B receptor dual antagonist
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AB-928

Item No. 31444

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[2-amino-6-[1-[[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]methyl]-1H-1,2,3-triazol-4-yl]-4-pyrimidinyl]-2-methyl-benzonitrile
CAS Number
2239273-34-6
Molecular Formula
C23H22N8O
Formula Weight
426.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
λmax
215 nm
SMILES
N#CC1=CC=CC(C2=NC(N)=NC(C3=CN(CC4=CC=CC(C(C)(O)C)=N4)N=N3)=C2)=C1C
InChi Code
InChI=1S/C23H22N8O/c1-14-15(11-24)6-4-8-17(14)18-10-19(28-22(25)27-18)20-13-31(30-29-20)12-16-7-5-9-21(26-16)23(2,3)32/h4-10,13,32H,12H2,1-3H3,(H2,25,27,28)
InChi Key
BUXIAWLTBSXYSW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    AB-928 is an adenosine A2A and A2B receptor dual antagonist.1 It inhibits the ability of adenosine (Item No. 21232) to suppress activation of human CD4 or CD8 T cells, as well as monocyte-derived dendritic cells, in vitro.2,3 AB-928, alone or in combination with doxorubicin (Item No. 15007), reduces tumor growth in an AT3-OVA syngeneic mouse model. It also acts synergistically with an anti-PD-1 antibody to reduce tumor growth in a B16/F10 syngeneic mouse model.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seitz, L., Jin, L., Leleti, M., et al. Safety, tolerability, and pharmacology of AB928, a novel dual adenosine receptor antagonist, in a randomized, phase 1 study in healthy volunteers. Invest. New Drugs 37(4), 711-721 (2019).

    2. Walters, M.J., Piovesan, D., Tan, J., et al. Abstract 5556: Combining adenosine receptor inhibition with AB928 and chemotherapy results in greater immune activation and tumor control. Cancer Res. 78(13 Suppl.), (2018).

    3. DiRenzo, D., Piovesan, D., Tan, J., et al. Abstract A162: AB928, a dual antagonist of the A2aR and A2bR adenosine receptors, relieves adenosine-mediated immune suppression. Cancer Immunol. Res. 7(2 Suppl.), (2019).