A PKC inhibitor
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LXS-196

Item No. 31455

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-amino-N-[3-(4-amino-4-methyl-1-piperidinyl)-2-pyridinyl]-6-[3-(trifluoromethyl)-2-pyridinyl]-2-pyrazinecarboxamide
CAS Number
1874276-76-2
Molecular Formula
C22H23F3N8O
Formula Weight
472.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
λmax
288, 375 nm
SMILES
O=C(C1=C(N)N=CC(C2=C(C(F)(F)F)C=CC=N2)=N1)NC3=NC=CC=C3N4CCC(C)(CC4)N
InChi Code
InChI=1S/C22H23F3N8O/c1-21(27)6-10-33(11-7-21)15-5-3-9-29-19(15)32-20(34)17-18(26)30-12-14(31-17)16-13(22(23,24)25)4-2-8-28-16/h2-5,8-9,12H,6-7,10-11,27H2,1H3,(H2,26,30)(H,29,32,34)
InChi Key
XXJXHXJWQSCNPX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $55

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    5 mg

    $203

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    10 mg

    $349

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    25 mg

    $736

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    Product Description

    LXS-196 is a PKC inhibitor (IC50s = 1.9 and 0.4 nM for PKCα and PKCθ, respectively).1 It is selective for PKCα and PKCθ over GSK3β (IC50 = 3,100 nM). It inhibits proliferation of TMD8 B cell lymphoma and 92.1 uveal melanoma cells (IC50s = 900 and 184 nM, respectively) but not SK-MEL-28 skin melanoma cells (IC50 = >10,000 nM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Luzzio, M.J., Papillon, J., and Visser, M.S. Protein kinase C inhibitors and methods of their use. (2016).