A derivative of DL-homocysteine
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DL-Homocysteine thiolactone (hydrochloride)

Item No. 31466

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-aminodihydro-2(3H)-thiophenone, monohydrochloride
CAS Number
6038-19-3
Synonyms
  • DL-Hcy thiolactone
  • DL-Hcy TLHC
  • NSC 22879
Molecular Formula
C4H7NOS • HCl
Formula Weight
153.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
237 nm
SMILES
O=C1SCCC1N.Cl
InChi Code
InChI=1S/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H
InChi Key
ZSEGSUBKDDEALH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 g

    $69

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    100 g

    $106

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    250 g

    $248

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    500 g

    $461

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    Product Description

    DL-Homocysteine thiolactone is a derivative of DL-homocysteine (Item No. 30285).1 It inhibits the growth of B. campestris, L. sativa, and E. utilis roots when used at a concentration of 50 µM.2 DL-Homocysteine thiolactone (10 µM) decreases the maximum rate of left ventricular developed pressure, systolic left ventricular pressure, and coronary flow in isolated rat hearts.3 It induces arteriosclerotic plaque formation in rabbits when administered at a dose of 30 mg/kg for eight weeks.1 DL-Homocysteine thiolactone has also been used as a precursor in the synthesis of thiolactone-containing monomers for use in polymer-based formaldehyde-scavenging coatings.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. McCully, K.S., and Wilson, R.B. Homocysteine theory of arteriosclerosis. Atherosclerosis 22(2), 215-227 (1975).

    2. Inamori, Y., Muro, C., Toyoda, M., et al. Root-growth inhibition by ᴅʟ-homocysteine thiolactone and its related compounds. Biosci. Biotech. Biochem. 59(3), 523-525 (1995).

    3. Zivkovic, V., Jakovljevic, V., Pechanova, O., et al. Effects of DL-homocysteine thiolactone on cardiac contractility, coronary flow, and oxidative stress markers in the isolated rat heart: The role of different gasotransmitters. Biomed. Res. Int. 318471 (2013).

    4. Resetco, C., Frank, D., Dikić, T., et al. Thiolactone-based polymers for formaldehyde scavenging coatings. Eur. Polym. J. 82, 166-174 (2016).