A synthetic peptide derivative of GHRH
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

CJC-1295-DAC (triflouroacetate)

Item No. 31497

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-D-alanyl-L-α-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-glutaminyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-leucyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-isoleucyl-L-leucyl-L-seryl-L-arginyl-N-[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]-L-lysinamide, trifluoroacetate
Synonyms
  • DAC-GRF
Molecular Formula
C165H269N47O46 • XCF3OOH
Formula Weight
3647.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
YaDAIFTQSYRKVLAQLSARKLLQDILSRL-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
NC([C@H](CCCCNC(CCN1C(C=CC1=O)=O)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CO)NC([C@@H](NC([C@](NC([C@H](CC(O)=O)NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](CCCCN[H])NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@@H](NC([C@@H](NC([C@H](C(C)C)NC([C@H](CCCCN[H])NC([C@H](CCCNC(N)=N)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@@]([C@H](O)C)([H])NC([C@@H](NC([C@](NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](NC([C@H](CC3=CC=C(O)C=C3)N[H])=O)C)=O)=O)C)=O)([H])[C@@H](C)CC)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)C)=O)=O)CC(C)C)=O)=O)C)=O)=O)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)([H])[C@@H](C)CC)=O)CC(C)C)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C165H269N47O46.C2HF3O2/c1-22-87(15)130(209-137(233)92(20)185-148(244)116(76-127(225)226)196-136(232)89(17)183-138(234)99(168)73-95-44-48-97(217)49-45-95)160(256)204-115(74-94-36-25-24-26-37-94)154(250)211-132(93(21)216)162(258)195-108(54-57-123(171)221)145(241)205-120(80-215)158(254)200-114(75-96-46-50-98(218)51-47-96)153(249)192-105(43-35-66-182-165(177)178)141(237)191-102(40-28-31-62-167)146(242)208-129(86(13)14)159(255)202-109(68-81(3)4)147(243)184-90(18)135(231)189-106(52-55-121(169)219)143(239)198-112(71-84(9)10)151(247)206-118(78-213)156(252)186-91(19)134(230)188-103(41-33-64-180-163(173)174)140(236)190-101(39-27-30-61-166)142(238)197-111(70-83(7)8)150(246)199-110(69-82(5)6)149(245)194-107(53-56-122(170)220)144(240)201-117(77-128(227)228)155(251)210-131(88(16)23-2)161(257)203-113(72-85(11)12)152(248)207-119(79-214)157(253)193-104(42-34-65-181-164(175)176)139(235)187-100(133(172)229)38-29-32-63-179-124(222)60-67-212-125(223)58-59-126(212)224;3-2(4,5)1(6)7/h24-26,36-37,44-51,58-59,81-93,99-120,129-132,213-218H,22-23,27-35,38-43,52-57,60-80,166-168H2,1-21H3,(H2,169,219)(H2,170,220)(H2,171,221)(H2,172,229)(H,179,222)(H,183,234)(H,184,243)(H,185,244)(H,186,252)(H,187,235)(H,188,230)(H,189,231)(H,190,236)(H,191,237)(H,192,249)(H,193,253)(H,194,245)(H,195,258)(H,196,232)(H,197,238)(H,198,239)(H,199,246)(H,200,254)(H,201,240)(H,202,255)(H,203,257)(H,204,256)(H,205,241)(H,206,247)(H,207,248)(H,208,242)(H,209,233)(H,210,251)(H,211,250)(H,225,226)(H,227,228)(H4,173,174,180)(H4,175,176,181)(H4,177,178,182);(H,6,7)/t87-,88-,89+,90-,91-,92-,93+,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,129-,130-,131-,132-;/m0./s1
InChi Key
GTJUHVQYIQLLSI-MCBIPECGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $40

    Add

    5 mg

    $120

    Add

    10 mg

    $200

    Add

    25 mg

    $450

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    CJC-1295-DAC is a synthetic peptide derivative of growth hormone-releasing hormone (GHRH) that contains a maleimidopropionic acid (MPA) moiety, which functions as a drug affinity complex (DAC).1 The DAC binds serum albumin, increasing the stability of the bioactive peptide in rat plasma. CJC-1295-DAC increases plasma GH levels in rats and increases pituitary GH levels, serum insulin-like growth factor (IGF-1) levels, body weight, and body length in GHRH knockout mice.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jetté, L., Léger, R., Thibaudeau, K., et al. Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: Identification of CJC-1295 as a long-lasting GRF analog. Endocrinology 146(7), (2005).

    2. Alba, M., Fintini, D., Sagazio, A., et al. Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. Am. J. Physiol. Endocrinol. Metab. 291(6), E1290-1294 (2006).