A metabolite of glucose
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Isomer(s)
34416D-Galacturonic Acid (hydrate)
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D-Glucuronic Acid

Item No. 31531

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
6556-12-3
Synonyms
  • D-(+)-Glucuronic Acid
Molecular Formula
C6H10O7
Formula Weight
194.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solublePBS (pH 7.2): 10 mg/ml
SMILES
O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O
InChi Code
InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h1-5,8-11H,(H,12,13)/t2-,3+,4-,5-/m0/s1
InChi Key
IAJILQKETJEXLJ-QTBDOELSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 g

    $41

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    10 g

    $75

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    50 g

    $351

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    100 g

    $659

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    Product Description

    D-Glucuronic acid is a metabolite of glucose.1,2 It is formed from glucose in a multi-step process in which uridine diphosphate glucose (UDP-α-D-glucose; Item No. 15602) is dehydrogenated to uridine diphosphate glucuronic acid (uridine-5’-diphosphoglucuronic acid; Item No. 20674), from which D-glucuronic acid can be transferred to a receptor to form glucuronides, further metabolized to ascorbic acid or xylulose, or excreted.1 D-Glucuronic acid is a component of proteoglycans, including heparan sulfate and chondroitin sulfate.3 Levels of D-glucuronic acid are increased in fibroblasts isolated from patients with infantile free sialic acid storage disease (ISSD) or Salla disease, lysosomal storage disorders characterized by truncal ataxia and psychomotor retardation and heptatosplenomegaly and impaired growth, respectively.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Miettinen, T.A., and Leskinen, E. Enzyme levels of glucuronic acid metabolism in the liver, kidney and intestine of normal and fasted rats. Biochem. Pharmacol. 12(6), 565-575 (1963).

    2. Dutton, G.J., and Storey, I.D.E. Glucuronide-forming enzymes: UDPglucuronic acid + R·OH → UDP + R·O· glucuronic acid. Methods in Enzymology 5, 159-164 (1962).

    3. Kwok, J.C.F., Warren, P., and Fawcett, J.W. Chondroitin sulfate: A key molecule in the brain matrix. Int. J. Biochem. Cell Biol. 44(4), 582-586 (2012).

    4. Blom, H.J., Andersson, H.C., Seppala, R., et al. Defective glucuronic acid transport from lysosomes of infantile free sialic acid storage disease fibroblasts. Biochem. J. 268(3), 621-625 (1990).