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Item No. 15602

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UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y14 receptor (EC50 = 0.35 μM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells.1 It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.2
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1. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009).
2. The recently identified P2Y-