A P2Y14 agonist
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UDP-α-D-Glucose (sodium salt hydrate)

Item No. 15602

Technical Information
Formal Name
uridine 5’-(trihydrogen diphosphate), P’-α-D-glucopyranosyl ester, disodium salt, hydrate
Synonyms
  • UDPG
  • UDP-Glucose
  • Uridine-5'-diphosphoglucose
Molecular Formula
C15H22N2O17P2 • 2Na [XH2O]
Formula Weight
Purity
≥98%
Formulation
A crystalline solid
PBS (pH 7.2): 10 mg/ml
λmax
262 nm
SMILES
O[C@H]1[C@H](O)[C@@H](CO)O[C@H](OP(OP(OC[C@@H]2[C@@H](O)[C@@H](O)[C@H](N3C=CC(NC3=O)=O)O2)([O-])=O)([O-])=O)[C@@H]1O.[Na+].[Na+].O
InChi Code
InChI=1S/C15H24N2O17P2.2Na.H2O/c18-3-5-8(20)10(22)12(24)14(32-5)33-36(28,29)34-35(26,27)30-4-6-9(21)11(23)13(31-6)17-2-1-7(19)16-15(17)25;;;/h1-2,5-6,8-14,18,20-24H,3-4H2,(H,26,27)(H,28,29)(H,16,19,25);;;1H2/q;2*+1;/p-2/t5-,6-,8-,9-,10+,11-,12-,13-,14-;;;/m1.../s1
InChi Key
SRHFBUUOPANXBG-WSIJJEQHSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    UDP-α-D-Glucose is an endogenous nucleotide sugar involved in glycosyltransferase reactions in metabolism. It has been shown to bind the P2Y14 receptor (EC50 = 0.35 μM), an atypical P2Y receptor involved in the activation of dendritic cells and glial cells.1 It can also bind to and activate GPR17, inducing oligodendrocyte differentiation at a maximal concentration of 100 μM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jacobson, K.A., Ivanov, A.A., de Castro, S., et alDevelopment of selective agonists and antagonists of P2Y receptors. Purinergic Signal. 5(1), 75-89 (2009).

    2. Lecca, D., Trincavelli, M.L., Gelosa, P., et alThe recently identified P2Y-like receptor GPR17 is a sensor of brain damage and a new target for brain repair. PLoS One 3(10), (2008).