A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications
Features
  • Purpose built for quantitative mass spectrometry
  • Prepared gravimetrically as a solution with a defined concentration
  • Packaged in an ampule sealed under argon to maintain product integrity
  • Guaranteed to meet MaxSpec® identity, purity, stability, and concentration
Related Products
Research Tool(s)
20294Hyodeoxycholic Acid
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Hyodeoxycholic Acid MaxSpec® Standard

Item No. 31606

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3α,5β,6α)-3,6-dihydroxy-cholan-24-oic acid
CAS Number
83-49-8
Synonyms
  • α-Hyodeoxycholic Acid
  • HDCA
  • NSC 60672
Molecular Formula
C24H40O4
Formula Weight
392.6
Purity
≥95%
Formulation (Request formulation change)
A solution in methanol at 100 µg/ml
SMILES
C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])C[C@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C24H40O4/c1-14(4-7-22(27)28)17-5-6-18-16-13-21(26)20-12-15(25)8-10-24(20,3)19(16)9-11-23(17,18)2/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16+,17-,18+,19+,20+,21+,23-,24-/m1/s1
InChi Key
DGABKXLVXPYZII-SIBKNCMHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    100 µg

    $103

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    Cayman Chemical
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    Product Description

    Hyodeoxycholic acid (HDCA) is a secondary bile acid.1 It is produced from lithocholic acid (Item No. 20253) by gut bacteria.1,2,3 Dietary administration of HDCA (1.25% w/w) decreases plasma VLDL and LDL cholesterol levels and reduces fasting glucose levels and atherosclerotic lesion size in LDL receptor knockout mice fed a Western diet.4 Serum levels of HDCA are increased in patients with Crohn’s disease or ulcerative colitis.5

    Hyodeoxycholic acid MaxSpec® standard is a quantitative grade standard of Hyodeoxycholic Acid (Item No. 20294) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. The verified concentration is provided on the certificate of analysis. This hyodeoxycholic acid MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Einarsson, K. On the formation of hyodeoxycholic acid in the rat. Bile acids and steroids 154. The Journal of Biological Chemisty 241(3), 534-539 (1966).

    2. Madsen, D., Beaver, M., Chang, L., et al. Analysis of bile acids in conventional and germfree rats. J. Lipid. Res. 17(2), 107-111 (1976).

    3. Sacquet, E., Parquet, M., Riottot, M., et al. Intestinal absorption, excretion, and biotransformation of hyodeoxycholic acid in man. J. Lipid. Res. 24(5), 604-613 (1983).

    4. Shih, D.M., Shaposhnik, Z., Meng, Y., et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. The FASEB Journal 27(9), 3805-3817 (2013).

    5. Gnewuch, C., Liebisch, G., Langmann, T., et al. Serum bile acid profiling reflects enterohepatic detoxification state and intestinal barrier function in inflammatory bowel disease. World J. Gastroenterol. 15(25), 3134-3141 (2009).