A BTK inhibitor
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BIIB068

Item No. 31619

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1-methylethoxy)-N-[[2-methyl-4-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]phenyl]methyl]-1-azetidinecarboxamide
CAS Number
1798787-27-5
Molecular Formula
C23H29N7O2
Formula Weight
435.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:4): 0.20 mg/mlEthanol: 10 mg/ml
λmax
274 nm
SMILES
O=C(N1CC(C1)OC(C)C)NCC2=C(C)C=C(C3=NC(NC4=CN(C)N=C4)=NC=C3)C=C2
InChi Code
InChI=1S/C23H29N7O2/c1-15(2)32-20-13-30(14-20)23(31)25-10-18-6-5-17(9-16(18)3)21-7-8-24-22(28-21)27-19-11-26-29(4)12-19/h5-9,11-12,15,20H,10,13-14H2,1-4H3,(H,25,31)(H,24,27,28)
InChi Key
BMWMKGNVAMXXCH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $257

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    10 mg

    $481

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    Product Description

    BIIB068 is an inhibitor of Bruton’s tyrosine kinase (BTK; IC50 = <10 nM).1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, C., Franklin, L., Chen, R., et al. Process development and large-scale synthesis of BTK inhibitor BIIB068. Org. Process Res. Dev. 24(6), 1199-1206 (2020).

    2. Hopkins, B.T., Ma, B., Chan, T.R., et al. Biaryl compounds useful for the treatment of human diseases in oncology, neurology, and immunology. (2015).