Cetilistat

Cetilistat is an inhibitor of pancreatic lipase (IC₅₀s = 5.95 and 54.8 nM for the human and rat enzymes, respectively).¹ It reduces increases in plasma triglyceride levels in an oral fat tolerance test, indicating decreased intestinal fat absorption, in rats when administered at a doses ranging from 3 to 100 mg/kg. Dietary administration of cetilistat (4.9-50.7 mg/kg per day) decreases body weight gain without affecting food intake, as well as reduces increases in plasma triglyceride and leptin levels in a rat model of high-fat diet-induced obesity. It also reduces viral load in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC₉₀ = 2.9 µM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC₅₀ = 1.13 µM).²

WARNING This product is not for human or veterinary use.

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