An alkaloid with diverse biological activities
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Psychotridine

Item No. 31645

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2′,2′′,2′′′,2′′′′,3,3′,3′′,3′′′,3′′′′,8,8′,8′′,8′′′,8′′′′,8a,8′a,8′′a,8′′′a,8′′′′a-eicosahydro-1,1′,1′′,1′′′,1′′′′-pentamethyl-3a(1H),7′:3′a,3′′a(1′H,1′′H):7′′,3′′′a(1′′′H):7′′′,3′′′′a(1′′′′H)-quinquepyrrolo[2,3-b]indole, stereoisomer
CAS Number
52617-25-1
Molecular Formula
C55H62N10
Formula Weight
863.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
SMILES
CN(CCC12C3=CC=CC4=C3NC5N(CCC45C6=CC=CC7=C6NC8N(CCC78C9%10C%11=C(NC9N(CC%10)C)C(C%12%13C%14=C(NC%12N(CC%13)C)C=CC=C%14)=CC=C%11)C)C)C2NC%15=C1C=CC=C%15
InChi Code
InChI=1S/C55H62N10/c1-61-28-23-51(33-13-6-8-21-41(33)56-46(51)61)35-15-10-16-36-43(35)58-48-53(36,25-30-63(48)3)38-18-12-20-40-45(38)60-50-55(40,27-32-65(50)5)54-26-31-64(4)49(54)59-44-37(17-11-19-39(44)54)52-24-29-62(2)47(52)57-42-22-9-7-14-34(42)52/h6-22,46-50,56-60H,23-32H2,1-5H3
InChi Key
DVJSMVZSIBHXAO-UHFFFAOYSA-N
Origin
Plant/Psychotria beccarioides
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $255

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    5 mg

    $885

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    Product Description

    Psychotridine is an alkaloid that has been found in P. forsteriana and has diverse biological activities.1,2,3 It inhibits ADP-, collagen-, or thrombin-induced aggregation of washed isolated human platelets with IC50 values of 1.4, 1.4, and 3.9 µM, respectively.1 Psychotridine (2.5 or 5 µM) is cytotoxic to HTC rat hepatocellular carcinoma cells.2 It reduces paw licking induced by capsaicin (Item Nos. 92350 | 10010743) in mice when administered at doses of 0.5, 2.5, or 5 mg/kg.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Beretz, A., Roth-Georger, A., Corre, G., et al. Polyindolinic alkaloids from Psychotria forsteriana. Potent inhibitors of the aggregation of human platelets. Planta Med. 51(4), 300-303 (1985).

    2. Roth, A., Kuballa, B., Bounthanh, C., et al. Cytotoxic activity of polyindoline alkaloids of Psychotria forsteriana (Rubiaceae) (1). Planta Med. 6, 450-453 (1986).

    3. Amador, T.A., Verotta, L., Nunes, D.S., et al. Involvement of NMDA receptors in the analgesic properties of psychotridine. Phytomedicine 8(3), 202-206 (2001).