A building block
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Enantiomer(s)
31694L-Pyrohomoglutamic Acid
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D-Pyrohomoglutamic Acid

Item No. 31693

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2R)-6-oxo-2-piperidinecarboxylic acid
CAS Number
72002-30-3
Synonyms
  • D-pHgu
  • (R)-6-Oxopiperidine-2-carboxylic Acid
Molecular Formula
C6H9NO3
Formula Weight
143.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
OC([C@@H]1NC(CCC1)=O)=O
InChi Code
InChI=1S/C6H9NO3/c8-5-3-1-2-4(7-5)6(9)10/h4H,1-3H2,(H,7,8)(H,9,10)/t4-/m1/s1
InChi Key
FZXCPFJMYOQZCA-SCSAIBSYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $55

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    100 mg

    $98

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    250 mg

    $215

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    500 mg

    $376

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    Product Description

    D-Pyrohomoglutamic acid is a building block.1 It has been used in the synthesis of immunoproteasome low molecular mass polypeptide 2 (LMP2) subunit inhibitors and is a component of substance P (Item No. 24035) peptide analogs.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, H.W.B., Anderl, J.L., Bradley, E.K., et al. Discovery of highly selective inhibitors of the immunoproteasome low molecular mass polypeptide 2 (LMP2) subunit. ACS Med. Chem. Lett. 8(4), 413-417 (2017).

    2. Hashimoto, T., Uchida, Y., Nishijima, M., et al. Syntheses and biological activities of substance P analogs containing L- and D-homoglutamine and L- and D-pyrohomoglutamic acid at position 5 and 6. B. Chem. Soc. Jpn. 60(3), 1207-1209 (1987).