An ACE and NEP inhibitor
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Omapatrilat

Item No. 31738

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4S,7S,10aS)-octahydro-4-[[(2S)-2-mercapto-1-oxo-3-phenylpropyl]amino]-5-oxo-7H-pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid
CAS Number
167305-00-2
Synonyms
  • BMS-186716
Molecular Formula
C19H24N2O4S2
Formula Weight
408.5
Purity
≥90%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/ml
SMILES
OC([C@H]1N2[C@](SCC[C@@H](C2=O)NC([C@@H](S)CC3=CC=CC=C3)=O)([H])CCC1)=OOC([C@H]1N2[C@](SCC[C@@H](C2=O)NC([C@@H](S)CC3=CC=CC=C3)=O)([H])CCC1)=O
InChi Code
InChI=1S/C19H24N2O4S2/c22-17(15(26)11-12-5-2-1-3-6-12)20-13-9-10-27-16-8-4-7-14(19(24)25)21(16)18(13)23/h1-3,5-6,13-16,26H,4,7-11H2,(H,20,22)(H,24,25)/t13-,14-,15-,16-/m0/s1
InChi Key
LVRLSYPNFFBYCZ-VGWMRTNUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $49

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    1 mg

    $93

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    5 mg

    $259

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    10 mg

    $469

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    Product Description

    Omapatrilat is an orally bioavailable angiotensin-converting enzyme (ACE) and neprilysin (NEP) inhibitior (IC50s = 1.7 and 5.3 nM, respectively, for the human enzymes).1 It inhibits the pressor response induced by angiotensin I (Item No. 24737) in normotensive rats (ED50 = 0.07 µmol/kg) and lowers mean arterial pressure (MAP) in sodium-depleted spontaneously hypertensive rats when administered at a dose of 30 µmol/kg.2 Omapatrilat lowers MAP in rats when co-administered with bradykinin (Item No. 37408).3 It also increases tracheal plasma extravasation in a rat model of upper airway angioedema in a dose-dependent manner.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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