A diterpene alkaloid with diverse biological activities
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Delsoline

Item No. 31748

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1α,6β,14α,16β)-20-ethyl-6,14,16-trimethoxy-4-(methoxymethyl)-aconitane-1,7,8-triol
CAS Number
509-18-2
Synonyms
  • Acomonine
Molecular Formula
C25H41NO7
Formula Weight
467.6
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: solubleMethanol: soluble
SMILES
O[C@@H](CC1)C(C(N2CC)C3(O)[C@H]4OC)([C@@](C[C@H]5[C@]6([H])OC)([H])[C@H]6[C@@]3(C[C@@H]5OC)O)[C@@]4([H])[C@@]1(C2)COC
InChi Code
InChI=1S/C25H41NO7/c1-6-26-11-22(12-30-2)8-7-16(27)24-14-9-13-15(31-3)10-23(28,17(14)18(13)32-4)25(29,21(24)26)20(33-5)19(22)24/h13-21,27-29H,6-12H2,1-5H3/t13-,14-,15+,16+,17-,18+,19-,20+,21?,22+,23-,24?,25?/m1/s1
InChi Key
JVBLTQQBEQQLEV-WZROKYDKSA-N
Origin
Plant/Aconitum carmichaelii
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Delsoline is a diterpene alkaloid that has been found in Delphinium and has diverse biological activities.1,2,3 It inhibits binding of α-bungarotoxin (Item No. 16385) to rat neuronal α7 nicotinic acetylcholine receptors (nAChRs; IC50 = 19 µM).1 Delsoline (3 mg/ml) is repellent against adult red flour beetles (T. castaneum) in a filter paper assay.2 In vivo, delsoline (75 mg/kg) lowers systolic blood pressure in a rat model of left renal artery ligation-induced hypertension.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hardick, D.J., Blagbrough, I.S., Cooper, G., et al. Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal alpha-bungarotoxin binding sites: Importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding. J. Med. Chem. 39(24), 4860-4866 (1996).

    2. Ulubelen, A., Meriçli, A.H., Kilinçer, N., et al. Insect repellent activity of diterpenoid alkaloids. Phytother. Res. 15(2), 170-171 (2001).

    3. Lian, Q.S., and Feng, G.H. Hypotensive effect of delsoline. Zhongguo Yaoli Xuebao 6(1), 37-40 (1985).