A fungal metabolite
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Piliformic Acid

Item No. 31756

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2E-hexylidene-3-methyl-butanedioic acid
CAS Number
98985-76-3
Molecular Formula
C11H18O4
Formula Weight
214.3
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
SMILES
OC(C(C)/C(C(O)=O)=C\CCCCC)=O
InChi Code
InChI=1S/C11H18O4/c1-3-4-5-6-7-9(11(14)15)8(2)10(12)13/h7-8H,3-6H2,1-2H3,(H,12,13)(H,14,15)/b9-7+
InChi Key
YTUQECDNJQCQAE-VQHVLOKHSA-N
Origin
Fungus/Unidentified sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $236

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    2.5 mg

    $876

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    Product Description

    Piliformic acid is a fungal metabolite that has been found in N. pseudotrichia and has diverse biological activities.1,2 It is cytotoxic to BC-1 human breast cancer cells (IC50 = 5 µg/ml).2 Piloformic acid is active against L. braziliensis amastigotes (IC50 = 78.5 µM). It is also active against the plant pathogenic fungi C. gloeosporioides (MIC = 292 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Elias, L.M., Fortkamp, D., Sartori, S.B., et al. The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnose. Braz. J. Microbiol. 49(4), 840-847 (2018).

    2. Cota, B.B., Tunes, L.G., Maia, D.N.B., et al. Leishmanicidal compounds of Nectria pseudotrichia, an endophytic fungus isolated from the plant Caesalpinia echinata (Brazilwood). Mem. Inst. Oswaldo Cruz 113(2), 102-110 (2018).