An inhibitor of HDAC6
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11076Epigenetics Screening Library (96-Well)
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NR-160

Item No. 31792

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[4-[(hydroxyamino)carbonyl]phenyl]methyl]-N-[[1-(phenylmethyl)-1H-tetrazol-5-yl]methyl]-2-(trifluoromethyl)-benzamide
CAS Number
2484895-50-1
Molecular Formula
C25H21F3N6O3
Formula Weight
510.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
SMILES
O=C(NO)C(C=C1)=CC=C1CN(CC2=NN=NN2CC3=CC=CC=C3)C(C4=C(C(F)(F)F)C=CC=C4)=O
InChi Code
InChI=1S/C25H21F3N6O3/c26-25(27,28)21-9-5-4-8-20(21)24(36)33(14-18-10-12-19(13-11-18)23(35)30-37)16-22-29-31-32-34(22)15-17-6-2-1-3-7-17/h1-13,37H,14-16H2,(H,30,35)
InChi Key
MEWDNULKAXEKII-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $90

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    10 mg

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    Product Description

    NR-160 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 0.03 µM).1 It is selective for HDAC6 over HDAC1, -2, -3, -4, and -8 (IC50s = 5.18, 2.26, 8.48, 55.4, and 14.7 µM, respectively). NR-160 is cytotoxic against a panel of seven cancer cell lines (IC50s = 22.5-51.8 µM). It enhances cytotoxicity induced by bortezomib (Item No. 10008822) in HL-60 cells, as well as cytotoxicity induced by epirubicin (Item No. 12091) or daunorubicin (Item No. 14159) in CCRF-HSB-2 T cell acute lymphoblastic leukemia cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Reßing, N., Sönnichsen, M., Osko, J.D., et al. Multicomponent synthesis, binding mode, and structure-activity relationship of selective histone deacetylase 6 (HDAC6) inhibitors with bifurcated capping groups. J. Med. Chem. 63(18), 10339-10351 (2020).