Active • Host: CHO cells • AA: 122-239 • MW: 13.2 kDa
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β-NGF (human, recombinant)

Item No. 32061

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • β-Nerve Growth Factor
  • NGFβ
Purity
≥95% estimated by SDS-PAGE
Endotoxin Testing
<1.0 EU/μg, determined by the LAL endotoxin assay
Source
Active recombinant human β-NGF expressed in CHO cells
Amino Acids
122-239
MW
13.2 kDa
Formulation (Request formulation change)
Lyophilized from sterile 40 mM His, 40 mM Arg, pH 5.5, with 150 mM sodium chloride and 5% Trehalose, 5% Mannitol, 0.01% Tween-80
UniProt Accession №
P01138
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    100 µg

    $192

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    1 mg

    $1,052

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    Product Description

    β-Nerve growth factor (β-NGF) is a neurotrophin that is involved in the regulation of growth, proliferation, and survival of sympathetic and sensory neurons.1 NGF encodes pro-NGF that is composed of an N-terminal signal peptide and α-, γ-, and β-NGF domains. β-NGF, also known as mature or functional NGF, is produced after degradation of the signaling peptide and proteolytic cleavage of pro-NGF at Ser122.2,3 β-NGF homodimerizes and induces neurotropic signaling through tropomyosin-related kinase A (TrkA) and the p75 neurotrophin receptor (p75NTR).3 β-NGF is produced by neurons in the cortex, pituitary gland, hippocampus, basal ganglia, thalamus, spinal cord, and retina, as well as in non-neuronal target cells of sympathetic and sensory neurons such as keratinocytes, vascular smooth muscle cells, exocrine salivary glands, and endocrine tissues.3,4 Exogenous administration of β-NGF improves neurological deficits in murine models of traumatic brain injury (TBI), and β-NGF levels in the cerebrospinal fluid of TBI patients are positively correlated with neurological outcomes.3 Exogenous administration of β-NGF also accelerates the rate of skin excision wound healing in rats. Cayman’s β-NGF (human, recombinant) protein can be used for cell-based assay applications. This protein consists of 118 amino acids and has a calculated molecular mass of 13.2 kDa.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bothwell, M. NGF, BDNF, NT3, and NT4. Neurotrophic Factors. Handbook of Experimental Pharmacology 220, 3-15 (2014).

    2. Ullrich, A., Gray, A., Berman, C., et al. Human β-nerve growth factor gene sequence highly homologous to that of mouse. Nature 303(5920), 821-825 (1983).

    3. Rocco, M.L., Soligo, M., Manni, L., et al. Nerve growth factor: Early studies and recent clinical trials. Curr. Neuropharmacol. 16(10), 1455-1465 (2018).

    4. Sofroniew, M.V., Howe, C.L., and Mobley, W.C. Nerve growth factor signaling, neuroprotection, and neural repair. Annu. Rev. Neurosci. 24, 1217-1281 (2001).