β-NGF (mouse, recombinant)

β-Nerve growth factor (β-NGF) is a neurotrophin that is involved in the regulation of growth, proliferation, and survival of sympathetic and sensory neurons.¹ Ngf encodes pro-NGF, a 27 kDa protein that is composed of an N-terminal signal peptide and α-, γ-, and β-NGF domains. β-NGF, also known as mature or functional NGF, is produced after degradation of the signaling peptide and proteolytic cleavage.^2,3 β-NGF homodimerizes and induces neurotropic signaling through tropomyosin-related kinase A (TrkA) and the p75 neurotrophin receptor (p75^NTR).⁴ β-NGF is produced by neurons in the cortex, pituitary gland, hippocampus, basal ganglia, thalamus, spinal cord, and retina, as well as in non-neuronal target cells of sympathetic and sensory neurons such as keratinocytes, vascular smooth muscle cells, exocrine salivary glands, and endocrine tissues.^4,5 Exogenous administration of β-NGF improves neurological deficits in murine models of traumatic brain injury (TBI).⁴ Exogenous administration of β-NGF also accelerates the rate of skin excision wound healing in rats. Cayman’s β-NGF (mouse, recombinant) protein can be used for cell-based assay applications. This protein consists of 121 amino acids and has a calculated molecular weight of 13.5 kDa.

WARNING This product is not for human or veterinary use.

1. Bothwell, M. NGF, BDNF, NT3, and NT4. Neurotrophic Factors. Handbook of Experimental Pharmacology 220, 3-15 (2014).

2. Ullrich, A., Gray, A., Berman, C., et al. Human β-nerve growth factor gene sequence highly homologous to that of mouse. Nature 303(5920), 821-825 (1983).

3. Bax, B., Blundell, T.L., Murray-Rust, J., et al. Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure 5(10), 1275-1285 (1997).

4. Rocco, M.L., Soligo, M., Manni, L., et al. Nerve growth factor: Early studies and recent clinical trials. Curr. Neuropharmacol. 16(10), 1455-1465 (2018).

5. Sofroniew, M.V., Howe, C.L., and Mobley, W.C. Nerve growth factor signaling, neuroprotection, and neural repair. Annu. Rev. Neurosci. 24, 1217-1281 (2001).