An internal standard for the quantification of 4-hydroxy nonenal
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Unlabeled Version(s)
321004-hydroxy Nonenal
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4-hydroxy Nonenal-d3

Item No. 332101

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(±)-4-hydroxy-9,9,9-d3-non-2E-enal
CAS Number
148706-06-3
Synonyms
  • FAL 9:1;O-d3
  • 4-HNE-d3
Molecular Formula
C9H13D3O2
Formula Weight
159.2
Purity
≥99% deuterated forms (d1-d3)
Formulation
A 500 µg/ml solution in methyl acetate
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlEthanol: 50 mg/mlPBS (pH 7.2): .5 mg/ml
λmax
220 nm
SMILES
[H]C(/C=C/C(O)CCCCC([2H])([2H])[2H])=O
InChi Code
InChI=1S/C9H16O2/c1-2-3-4-6-9(11)7-5-8-10/h5,7-9,11H,2-4,6H2,1H3/b7-5+/i1D3
InChi Key
JVJFIQYAHPMBBX-PKJLGKQPSA-N
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 µg

    $105

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    100 µg

    $189

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    500 µg

    $785

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    1 mg

    $1,254

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    Product Description

    4-hydroxy Nonenal-d3 (4-HNF-d3) contains three deuterium atoms at the terminal methyl position. It is intended for use as an internal standard for the quantification of 4-HNE by GC- or LC-mass spectrometry. 4-HNE is a lipid peroxidation product derived from oxidized ω-6 polyunsaturated fatty acids such as arachidonic acid.1,2 4-HNE is widely used as a marker of lipid peroxidation.2 It exhibits various biological activities such as cytotoxicity, growth inhibiting activity, genotoxicity, and chemotactic activity.1,2,3 4-HNE inhibits pro-oxidant-induced Ca2+ release from mitochondria at 10-50 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pryor, W.A., and Porter, N.A. Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic. Biol. Med. 8(6), 541-543 (1990).

    2. Esterbauer, H., Schaur, R.J., and Zoliner, H. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde, and related aldehydes. Free Radic. Biol. Med. 11(1), 81-128 (1991).

    3. Sodum, R.S., and Chung, F.L. 1,N2-ethenodeoxyguanosine as a potential marker for DNA adduct formation by trans-4-hydroxy-2-nonenal. Cancer Res. 48(2), 320-323 (1988).

    Product Citations

    Song, H., Wohltmann, M., Tan, M., et al. Group VIA phospholipase A2 mitigates palmitate-induced b-cell mitochondrial injury and apoptosis. The Journal of Biological Chemisty 289(20), 14194-14210 (2014).