For immunochemical detection of H3K36
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Histone H3K36Ac Monoclonal Antibody (RM154)

Item No. 32135

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Acetylated Histone H3 Lysine 36
Immunogen
Peptide corresponding to H3K36Ac
Clone Designation
RM154
Formulation (Request formulation change)
100 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ChIP, ELISA, ICC, multiplex-based assay, WB
Cross Reactivity
(+) H3K36Ac(+) H3K36Ac/S31Ph(-) Unmodified H3K36(-) Unmodified H3K4Ac(-) Unmodified K3K9Ac(-) Unmodified H3K14Ac(-) Unmodified H3K18Ac(-) Unmodified H3K23Ac(-) Unmodified H3K27Ac(-) Unmodified H3K56Ac(-) Unmodified H3K79Ac(-) Unmodified H3K122Ac
Species Reactivity
(+) Vertebrates
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $500

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    Product Description

    Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.1 It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.1,2 Acetylation of histone H3 at lysine 36 (H3K36Ac) is predominantly localized to the promoters of genes transcribed by RNA polymerase II and is highly conserved in mammals.3 Cayman's Histone H3K36Ac Monoclonal Antibody (RM154) can be used for chromatin immunoprecipitation (ChIP), ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyun, K., Jeon, J., Park, K., et al. Writing, erasing and reading histone lysine methylations. Exp. Mol. Med. 49(4), e324 (2017).

    2. Sharda, A., Amnekar, R.V., Natu, A., et al. Histone posttranslational modifications: Potential role in diagnosis, prognosis, and therapeutics of cancer. Prognostic Epigenetics 15, 351-373 (2019).

    3. Morris, S.A., Rao, B., Garcia, B.A., et al. Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. The Journal of Biological Chemisty 282(10), 7632-7640 (2007).