For immunochemical detection of H3K56Ac
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Histone H3K56Ac Monoclonal Antibody (RM179)

Item No. 32153

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Acetylated Histone H3 Lysine 56
Immunogen
Peptide corresponding to H3K56Ac
Clone Designation
RM179
Formulation (Request formulation change)
100 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA, ICC, IHC, multiplex-based assays, WB
Cross Reactivity
(+) H3K56Ac(-) Unmodified H3K56(-) H3K4Ac(-) H3K9Ac(-) H3K14Ac(-) H3K18Ac(-) H3K23Ac(-) H3K27Ac(-) H3K36Ac(-) H3K79Ac(-) H3K122Ac
Species Reactivity
(+) Vertebrates
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $500

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    Product Description

    Histone H3 is a nuclear protein and a component of the nucleosome core, a basic unit of chromatin, that is essential for organizing genomic DNA in eukaryotic nuclei.1 It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, and citrullination.1,2 Acetylation of histone H3 at lysine 56 (H3K56Ac) destabilizes the nucleosome core protein structure, which leads to unwrapping of histone octamers.3 H3K56Ac increases the affinity of various chromatin remodeling proteins for chromatin and is associated with transcriptional activation. Cayman’s Histone H3K56Ac Monoclonal Antibody (RM179) can be used for ELISA, immunocytochemistry (ICC), immunohistochemistry (IHC), multiplex-based assay, and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hyun, K., Jeon, J., Park, K., et al. Writing, erasing and reading histone lysine methylations. Exp. Mol. Med. 49(4), e324 (2017).

    2. Sharda, A., Amnekar, R.V., Natu, A., et al. Histone posttranslational modifications: Potential role in diagnosis, prognosis, and therapeutics of cancer. Prognostic Epigenetics 15, 351-373 (2019).

    3. Stejskal, S., Stepka, K., Tesarova, L., et al. Cell cycle-dependent changes in H3K56ac in human cells. Cell Cycle 14(24), 3851-3863 (2015).