For immunochemical detection of H2A.ZK7Ac
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Histone H2A.ZK7Ac Monoclonal Antibody (RM222)

Item No. 32172

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Acetylated Histone H2A.Z Lysine 7
Immunogen
Peptide corresponding to H2A.ZK7Ac
Clone Designation
RM222
Formulation (Request formulation change)
100 µg of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
ELISA, ICC, multiplex-based assays, WB
Cross Reactivity
(+) H2A.ZK7Ac(-) Unmodified H2A.Z (1-19)(-) H2A.ZK4Ac(-) H2A.ZK11Ac(-) H2A.ZK13Ac(-) H2A.XK5Ac(-) H2A.XK9Ac(-) H2A.XK36Ac
Species Reactivity
(+) Vertebrates
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µg

    $500

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    Product Description

    Histone H2A.Z is a highly conserved variant of the core histone H2A that comprises approximately 5% of the total H2A found in vertebrates.1 It is a globular protein that contains an unstructured N-terminal tail that extends outside of the nucleosome core and is subject to various post-translational modifications (PTMs), including methylation, phosphorylation, acetylation, SUMOylation and ubiquitination.2,3 Acetylation of histone H2A.Z at lysine 7 (H2A.ZK7Ac) by the lysine acetyltransferase TIP60 is associated with transcriptional activation.3,4 Cayman’s Histone H2A.ZK7Ac Monoclonal Antibody (RM222) can be used for ELISA, immunocytochemistry (ICC), multiplex-based assay, and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hatch, C.L., and Bonner, W.M. The human histone H2A.Z gene. Sequence and regulation. The Journal of Biological Chemisty 265(25), 15211-15218 (1990).

    2. Hyun, K., Jeon, J., Park, K., et al. Writing, erasing and reading histone lysine methylations. Exp. Mol. Med. 49(4), e324 (2017).

    3. Giaimo, B.D., Ferrante, F., Herchenröther, A., et al. The histone variant H2A.Z in gene regulation. Epigenetics Chromatin 12, 37 (2019).

    4. Colino-Sanguino, Y., Cornett, E.M., Moulder, D., et al. A read/write mechanism connects p300 bromodomain function to H2A.Z acetylation. iScience 21, 773-788 (2019).