For immunochemical detection of caveolin 1
Related Products
Alternative(s)
100830Caveolin-1/3 Polyclonal Antiserum
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Caveolin-1 (C-Term) Rabbit Monoclonal Antibody (Clone RM325)

Item No. 32263

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • CAV-1
Immunogen
Peptide from the C-terminal region of human caveolin 1
Clone Designation
RM325
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) Caveolin 1
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    Caveolin 1 is a hairpin membrane protein with roles in cell signaling and migration, extracellular matrix organization, cholesterol distribution, and endocytosis encoded by CAV1 in humans.1,2 It is composed of N- and C-terminal cytoplasmic tails separated by a hydrophobic segment embedded in the membrane and an N-terminal oligomerization domain that contains a caveolin scaffolding domain.2,3 It is ubiquitously expressed, with the highest levels in adipocytes, endothelial cells, and pneumocytes, and is localized to plasma membrane caveolae and the Golgi apparatus membrane. Caveolin 1 interacts with cholesterol to facilitate cholesterol transport and the organization of lipid rafts, as well as various G proteins, kinases, hormone receptors, and nitric oxide synthases, to modulate cellular signaling. CAV1 is overexpressed in liver, colon, kidney, lung, and breast cancers and acts as a tumor promoter or suppressor in a tumor type and/or stage-dependent manner.1 Cayman's Caveolin 1 (C-Term) Rabbit Monoclonal Antibody (Clone RM325) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nwosu, Z.C., Ebert, M.P., Dooley, S., et al. Caveolin-1 in the regulation of cell metabolism: A cancer perspective. Mol. Cancer 15(1), 71 (2016).

    2. Boscher, C., and Nabi, I.R. Caveolin-1: Role in cell signaling. Adv. Exp. Med. Biol. 729, 29-50 (2012).

    3. Branza-Nichita, N., Macovei, A., and Lazar, C. Caveolae-dependent endocytosis in viral infection. Molecular Regulation of Endocytosis (2012).