CD19 (C-Term) Rabbit Monoclonal Antibody (Clone RM332)

CD19 is a type I transmembrane protein and member of the immunoglobulin superfamily that functions as a B cell receptor (BCR) co-receptor.^1,2 It is composed of an extracellular N-terminal domain containing two C2-type immunoglobulin-like (Ig-like) domains and several glycosylation sites, a transmembrane domain, and a C-terminal cytoplasmic domain containing nine tyrosine residues, which are subject to phosphorylation and mediate intracellular signaling. It is expressed on the surface of, and used as a marker for, B cells, and its expression increases during B cell maturation but decreases upon plasma cell differentiation.^1,2,3 CD19 has important roles in B cell proliferation, differentiation, and survival.¹ It associates with CD21, also known as complement receptor 2 (CR2), as well as CD82 and Leu-13, forming a multimeric complex that enhances BCR signaling.^1,2 CD19 functions as an adaptor protein, recruiting various cytoplasmic signaling proteins to the cell membrane that activate numerous intracellular signaling pathways, including PI3K, MAPK, and NF-κB.^1,2,4 CD19 protein levels are increased in tumor cells isolated from patients with a variety of cancers of B cell origin, including chronic myelocytic leukemia and B cell lymphomas, and decreased in B cells isolated from patients with systemic lupus erythematosus (SLE).^5,6,3,2,1 Cayman’s CD19 (C-Term) Rabbit Monoclonal Antibody (Clone RM332) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

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1. Li, X., Ding, Y., Zi, M., et al. CD19, from bench to bedside. Immunol. Lett. 183, 86-95 (2017).

2. Wang, K., Wei, G., and Liu, D. CD19: A biomarker for B cell development, lymphoma diagnosis and therapy. Exp. Hematol. Oncol. 1(1), 36 (2012).

3. Poe, J.C., Minard-Colin, V., Kountikov, E.I., et al. A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice. J. Immunol. 89(5), 2318-2325 (2012).

4. Haas, K.M., and Tedder, T.F. Role of the CD19 and CD21/35 receptor complex in innate immunity, host defense and autoimmunity. Mechanisms of lymphocyte activation and immune regulation X 560, 125-139 (2005).

5. Anderson, K.C., Bates, M.P., Slaughenhoupt, B.L., et al. Expression of human B cell-associated antigens on leukemias and lymphomas: A model of human B cell differentiation. Blood 63(6), 1424-1433 (1984).

6. Korganow, A.-S., Knapp, A.-M., Nehme-Schuster, H., et al. Peripheral B cell abnormalities in patients with systemic lupus erythematosus in quiescent phase: Decreased memory B cells and membrane CD19 expression. J. Autoimmun. 34(4), 426-434 (2010).