c-Kit/CD117 (C-Term) Rabbit Monoclonal Antibody (Clone RM359)

c-Kit, also known as CD117, is a type III receptor tyrosine kinase involved in the proliferation, differentiation, and survival of hematopoietic cells.^1,2 It is composed of an N-terminal extracellular domain containing five immunoglobulin-like (Ig-like) domains, short transmembrane and juxtamembrane domains, and a C-terminal intracellular region containing the kinase domain. It is expressed in hematopoietic stem and progenitor cells, as well as certain non-hematopoietic tissues.² c-Kit is activated by the binding of its ligand, stem cell factor (SCF), to the extracellular region, which induces autophosphorylation and the recruitment of signaling molecules to the intracellular region.¹ c-Kit signal transduction activates a variety of signaling pathways, including the PI3K/Akt, RAS/MAPK, and JAK/STAT pathways.^1,2 Homozygous knockout of Kit, the gene encoding c-Kit, is embryonic lethal, with mice developing severe anemia in utero.³ KIT is considered a proto-oncogene and activating mutations have been associated with a variety of cancers.^1,2 Cayman’s c-Kit/CD117 (C-Term) Rabbit Monoclonal Antibody (Clone RM359) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.

1. Roskoski, R., Jr. Src protein-tyrosine kinase structure, mechanism, and small molecule inhibitors. Pharmacol. Res. 94, 9-25 (2015).

2. Edling, C.E., and Hallberg, B. c-Kit—a hematopoietic cell essential receptor tyrosine kinase. Int. J. Biochem. Cell Biol. 39(11), 1995-1998 (2007).

3. Russell, E.S. Hereditary anemias of the mouse: A review for geneticists. Adv. Genet. 20, 357-459 (1979).