For immunochemical detection of ALK
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ALK/CD246 (C-Term) Rabbit Monoclonal Antibody (Clone RM361)

Item No. 32287

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • ALK Tyrosine Kinase Receptor
  • Anaplastic Lymphoma Kinase
  • CD246
  • Cluster of Differentiation 246
Immunogen
Peptide from the C-terminal region of human ALK
Clone Designation
RM361
Formulation (Request formulation change)
100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide
Host
Rabbit
Isotype
IgG
Applications
IHC, WB
Cross Reactivity
(+) ALK(+) ALK fusion proteins
Species Reactivity
(+) Human
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    100 µl

    $411

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    Product Description

    Anaplastic lymphoma kinase (ALK), also known as CD246, is a receptor tyrosine kinase and member of the insulin receptor superfamily.1 It is composed of an N-terminal extracellular domain that participates in cell-cell interactions, as well as transmembrane and juxtamembrane domains, and a C-terminal intracellular region that contains the protein kinase domain. Full-length ALK is expressed primarily in the embryonic nervous system, but the ALK kinase domain is expressed in a variety of cell types in the adult as a fusion protein.1,2 ALK is involved in cell proliferation and survival through downstream activation of the ERK1/2 and JAK/STAT signaling pathways, respectively.1 The fusion protein nucleophosmin-ALK (NPM-ALK) has a constitutively active ALK kinase domain and is ectopically expressed in anaplastic large-cell lymphoma (ALCL), a type of non-Hodgkin lymphoma.3 A variety of ALK-based fusion proteins are associated with ALCL, non-small cell lung cancer (NSCLC), inflammatory myofibroblastic tumor (IMT), diffuse large B cell lymphoma (DLBCL), and other cancers.1 Activating mutations in, and overexpression of, ALK have been associated with childhood neuroblastomas. Cayman’s ALK/CD246 (C-Term) Rabbit Monoclonal Antibody (Clone RM361) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Roskoski, R., Jr. Anaplastic lymphoma kinase (ALK): Structure, oncogenic activation, and pharmacological inhibition. Pharmacol. Res. 68(1), 68-94 (2013).

    2. Vernersson, E., Khoo, N.K.S., Henriksson, M.L., et al. Characterization of the expression of the ALK receptor tyrosine kinase in mice. Gene Expr. Patterns 6(5), 448-461 (2006).

    3. Morris, S.W., Kirstein, M.N., Valentine, M.B., et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin’s lymphoma. Science 263(5151), 1281-1284 (1994).