For immunochemical detection of chromogranin A

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Chromogranin A (N-Term) Rabbit Monoclonal Antibody (Clone RM385)

Name: Chromogranin A (N-Term) Rabbit Monoclonal Antibody (Clone RM385)
Brand: -

Item No. 32312

Chromogranin A (N-Term) Rabbit Monoclonal Antibody (Clone RM385) (CGA, Parathyroid Secretory Protein 1, Pituitary Secretory Protein 1)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Synonyms

CGA
Parathyroid Secretory Protein 1
Pituitary Secretory Protein 1

Immunogen

Peptide from the N-terminal region of human chromogranin A

Clone Designation

RM385

Formulation (Request formulation change)

100 µl of protein A-affinity purified monoclonal antibody

Storage Buffer

PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide

Host

Rabbit

Isotype

IgG

Applications

IHC, WB

Cross Reactivity

(+) Chromogranin A

Species Reactivity

(+) Human

Shipping & Storage Information

Storage

-20°C

Shipping

Wet ice in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

100 µl

$411

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Product Description

Chromogranin A is a glycoprotein and member of the chromogranin/secretogranin family of neuroendocrine secretory proteins that is encoded by CHGA in humans.^1,2,3 It is expressed in endocrine, neuroendocrine, and immune cells and localized to secretory granules. Chromogranin A is composed of multiple peptide domains and is proteolytically cleaved by prohormone convertases, plasmin, kallikrein, and cathepsin L to generate various bioactive peptides, including pacreastatin, vasostatin-1, catestatin, and serpinin, which have roles in insulin sensitivity, vasodilation, inflammation, and cardiac contractility, respectively. Plasma levels of chromogranin A are increased in patients with hypertension, inflammatory bowel disease, rheumatoid arthritis, and severe sepsis, as well as carcinoid, pancreatic islet, or thyroid tumors.³ Cayman’s Chromogranin A (N-Term) Rabbit Monoclonal Antibody (Clone RM385) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Di Giacinto, P., Rota, F., Rizza, L., et al. Chromogranin A: From laboratory to clinical aspects of patients with neuroendocrine tumors. Int. J. Endocrinol. 8126087 (2018).

2. Eissa, N., Hussein, H., Hendy, G.N., et al. Chromogranin-A and its derived peptides and their pharmacological effects during intestinal inflammation. Biochem. Pharmacol. 152, 315-326 (2018).

3. Mahata, S.K., and Corti, A. Chromogranin A and its fragments in cardiovascular, immunometabolic, and cancer regulation. Ann. N. Y. Acad. Sci. 1455(1), 34-58 (2019).

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