A STING agonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

STING Agonist 1a

Item No. 32520

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-1-(2-chloro-6-methoxy-3-quinolinyl)-[1,2,4]triazolo[4,3-a]quinoxaline
CAS Number
652142-94-4
Synonyms
  • Stimulator of Interferon Genes Agonist 1a
Molecular Formula
C19H11Cl2N5O
Formula Weight
396.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: slightly solubleDMSO: slightly solublePBS (pH 7.2): slightly soluble
λmax
218, 250 nm
SMILES
ClC1=NC2=C(N3C1=NN=C3C4=C(Cl)N=C5C=CC(OC)=CC5=C4)C=CC=C2
InChi Code
InChI=1S/C19H11Cl2N5O/c1-27-11-6-7-13-10(8-11)9-12(16(20)22-13)18-24-25-19-17(21)23-14-4-2-3-5-15(14)26(18)19/h2-9H,1H3
InChi Key
ABGPUQXRCXUIFE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $54

    Add

    1 mg

    $96

    Add

    5 mg

    $392

    Add

    10 mg

    $732

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    STING agonist 1a is an agonist of stimulator of interferon genes (STING).1 It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50 = 16.77 µM). STING agonist 1a (12.5-100 µM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 (Item No. 25857).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hou, H., Yang, R., Liu, X., et al. Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screening. Bioorg. Chem. 100, 103958 (2020).