A BTK inhibitor
Related Products
Alternative(s)
32957ONO-4059
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ONO-4059 (hydrochloride)

Item No. 32818

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one, monohydrochloride
CAS Number
1439901-97-9
Synonyms
  • GS-4059
  • ONO-WG-307
Molecular Formula
C25H22N6O3 • HCl
Formula Weight
490.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 1 mg/mlDMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
215 nm
SMILES
NC1=C2C(N([C@@]3([H])CN(CC3)C(C#CC)=O)C(N2C4=CC=C(C=C4)OC5=CC=CC=C5)=O)=NC=N1.Cl
InChi Code
InChI=1S/C25H22N6O3.ClH/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19;/h3-5,7-12,16,18H,13-15H2,1H3,(H2,26,27,28);1H/t18-;/m1./s1
InChi Key
UQYDCIJFACDXSG-GMUIIQOCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $121

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    10 mg

    $215

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    25 mg

    $388

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    50 mg

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    Product Description

    ONO-4059 is an inhibitor of Bruton’s tyrosine kinase (BTK; IC50 = 2.2 nM).1 It is selective for BTK over LCK, LYN, and Fyn at 1 µM.2 ONO-4059 inhibits B cell proliferation and activation in vitro and reduces tumor growth in a TMD8 mouse xenograft model.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Burger, A. Bruton’s tyrosine kinase (BTK) inhibitors in clinical trials. Curr. Hematol. Malig. Rep. 9(1), 44-49 (2014).

    2. Yasuhiro, T., Yoshizawa, T., Daub, H., et al. Abstract 2021: ONO-WG-307, a novel, potent and selective inhibitor of Bruton’s tyrosine kinase (Btk), results in sustained inhibition of the ERK, AKT and PKD signaling pathways. Cancer Res. 72(8 Supplement), 2021 (2012).

    3. Kozaki, R., Yoshizawa, T., Tohda, S., et al. Abstract 3731: Development of a Bruton’s tyrosine kinase (Btk) inhibitor, ONO-WG-307: Efficacy in ABC-DLBCL xenograft model – potential treatment for B-cell malignancies. Blood 118(21), 3731 (2011).