A 5-HT1B receptor antagonist
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SB-216641 (hydrochloride)

Item No. 32837

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-[2-(dimethylamino)ethoxy]-4-methoxyphenyl]-2′-methyl-4′-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1′-biphenyl]-4-carboxamide, monohydrochloride
CAS Number
193611-67-5
Molecular Formula
C28H30N4O4 • HCl
Formula Weight
523.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: Slightly soluble: 0.1-1 mg/mlWater: soluble
SMILES
O=C(C1=CC=C(C2=C(C)C=C(C3=NOC(C)=N3)C=C2)C=C1)NC4=CC=C(C(OCCN(C)C)=C4)OC.Cl
InChi Code
InChI=1S/C28H30N4O4.ClH/c1-18-16-22(27-29-19(2)36-31-27)10-12-24(18)20-6-8-21(9-7-20)28(33)30-23-11-13-25(34-5)26(17-23)35-15-14-32(3)4;/h6-13,16-17H,14-15H2,1-5H3,(H,30,33);1H
InChi Key
JPBMDMNORXKGHZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $128

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    10 mg

    $196

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    Product Description

    SB-216641 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT1B.1 It binds to 5-HT1B receptors (Ki = 1 nM) and is selective for 5-HT1B over 5-HT1A, 5-HT1D, 5-HT1E, and 5-HT1F receptors in radioligand binding assays (Kis = 500, 25, >1,000, and >1,000 nM, respectively). SB-216641 (1-1,000 nM) reduces 5-HT-induced inhibition of forskolin-induced cAMP production in CHO cells expressing human 5-HT1B receptors.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Price, G.W., Burton, M.J., Collin, L.J., et al. SB-216641 and BRL-15572 – compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol. 356(3), 312-320 (1997).