A piscicide
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TFM

Item No. 32870

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-nitro-3-(trifluoromethyl)-phenol
CAS Number
88-30-2
Synonyms
  • NSC 59758
  • 3-(Trifluoromethyl)-4-Nitrophenol
Molecular Formula
C7H4F3NO3
Formula Weight
207.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
222, 292 nm
SMILES
OC(C=C1C(F)(F)F)=CC=C1[N+]([O-])=O
InChi Code
InChI=1S/C7H4F3NO3/c8-7(9,10)5-3-4(12)1-2-6(5)11(13)14/h1-3,12H
InChi Key
ZEFMBAFMCSYJOO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    50 mg

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    Cayman Chemical
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    Product Description

    TFM is a piscicide.1 It is toxic to sea lamprey (P. marinus) with LC50 values ranging from 1.97 to 2.11 and 2.05 to 2.21 mg/L for sac and swim-up fry, respectively, 1.6 to 2.45 mg/L for juveniles, and 1.6 to 1.63 mg/L for adults. It is also toxic to juvenile lake sturgeon (A. fulvescens) less than 100 mm in size but not to a variety of other fish species. TFM (50 µM) uncouples oxidative phosphorylation by 22 and 28% in isolated sea lamprey and rainbow trout (O. mykiss) liver, respectively.2 Formulations containing TFM have been used as lampricides in the control of larval sea lamprey populations.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Boogaard, M.A., Bills, T.D., and Johnson, D.A. Acute toxicity of TFM and a TFM/niclosamide mixture to selected species of fish, including lake sturgeon (Acipenser fulvescens) and mudpuppies (Necturus maculosus), in laboratory and field exposures. J. Great Lakes Res. 29(Suppl 1), 529-541 (2003).

    2. Birceanu, O., McClelland, G.B., Wang, Y.S., et al. The lampricide 3-trifluoromethyl-4-nitrophenol (TFM) uncouples mitochondrial oxidative phosphorylation in both sea lamprey (Petromyzon marinus) and TFM-tolerant rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 153(3), 342-349 (2011).