An anthraquinone with genotoxic and carcinogenic activities
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Isomer(s)
329062-Hydroxyanthraquinone
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1-Hydroxyanthraquinone

Item No. 32905

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-hydroxy-9,10-anthracenedione
CAS Number
129-43-1
Synonyms
  • NSC 8640
Molecular Formula
C14H8O3
Formula Weight
224.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: 30 mg/ml
λmax
217, 250 nm
SMILES
O=C1C2=C(C(C3=C1C=CC=C3O)=O)C=CC=C2
InChi Code
InChI=1S/C14H8O3/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7,15H
InChi Key
BTLXPCBPYBNQNR-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 g

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    Cayman Chemical
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    Product Description

    1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities.1,2 1-Hydroxyanthraquinone (5 and 500 µM) increases the percentage of isolated rat hepatocytes undergoing unscheduled DNA synthesis, indicating genotoxic activity.1 Dietary administration of 1-hydroxyanthraquinone (1%) induces formation of cecum and colon adenocarcinomas, as well as hepatocellular carcinomas, in rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawai, K., Mori, H., Sugie, S., et al. Genotoxicity in the hepatocyte/DNA repair test and toxicity to liver mitochondria of 1-hydroxyanthraquinone and several dihydroxyanthraquinones. Cell Biol. Toxicol. 2(4), 457-467 (1986).

    2. Mori, H., Yoshimi, N., Iwata, H., et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: Induction of large bowel, liver and stomach neoplasms. Carcinogenesis 11(5), 799-802 (1990).