An internal standard for the quantification of quetiapine
Related Products
Unlabeled Version(s)
14152Quetiapine (hemifumarate)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Quetiapine-d8 (fumarate)

Item No. 32946

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-(4-dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl-d8)ethoxy]-ethanol, 2E-butenedioate
CAS Number
1185247-12-4
Molecular Formula
C21H17D8N3O2S • C4H4O4
Formula Weight
507.6
Purity
≥99% deuterated forms (d1-d8)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: solubleDMSO: solubleMethanol: soluble
SMILES
OC(/C=C/C(O)=O)=O.OCCOCCN(C([2H])([2H])C1([2H])[2H])C([2H])([2H])C([2H])([2H])N1C2=NC(C=CC=C3)=C3SC4=C2C=CC=C4
InChi Code
InChI=1S/C21H25N3O2S.C4H4O4/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21;5-3(6)1-2-4(7)8/h1-8,25H,9-16H2;1-2H,(H,5,6)(H,7,8)/b;2-1+/i9D2,10D2,11D2,12D2;
InChi Key
VRHJBWUIWQOFLF-SMODUGIXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $362

    Add
    Product Description

    Quetiapine-d8 is intended for use as an internal standard for the quantification of quetiapine (Item No. 14152) by GC- or LC-MS. Quetiapine is an atypical, second generation antipsychotic compound.1,2,3 It has effects at multiple receptors, antagonizing dopamine D1, D2, and D3 receptors (Kis = 994, 379, and 340 nM, respectively), serotonin 5-HT1A, 5-HT2A, and 5-HT7 receptors (Kis = 394, 118, and 307 nM, respectively), and α1A, α1B, and α2C adrenergic receptors (Kis = 22, 15, and 29 nM, respectively).4,5 Quetiapine also potently antagonizes the histamine H1 receptor (Ki = 11 nM).5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seeman, P. Atypical antipsychotics: Mechanism of action. Can. J. Psychiatry 47(1), 27-38 (2002).

    2. Rummel-Kluge, C., Komossa, K., Schwarz, S., et al. Second-generation antipsychotic drugs and extrapyramidal side effects: A systematic review and meta-analysis of head-to-head comparisons. Schizophr. Bull. 38(1), 167-177 (2012).

    3. Cerejeira, J., and Mukaetova-Ladinska, E.B. A clinical update on delirium: From early recognition to effective management. Nurs. Res. Pract. 875196 (2011).

    4. Richelson, E., and Souder, T. Binding of antipsychotic drugs to human brain receptors: Focus on newer generation compounds. Life Sci. 68(1), 29-39 (2000).

    5. Kroeze, W.K., Hufeisen, S.J., Popadak, B.A., et al. H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology 28(3), 519-526 (2003).